脂肪干细胞在皮肤瘢痕防治中的研究进展
[Research progress of adipose-derived stem cells in skin scar prevention and treatment].
作者信息
He Tao, Yang Jiqiao, Liu Pengcheng, Xu Li, Lü Qing, Tan Qiuwen
机构信息
Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Feb 15;35(2):234-240. doi: 10.7507/1002-1892.202007083.
OBJECTIVE
To review the research progress of adipose-derived stem cells (ADSCs) in skin scar prevention and treatment.
METHODS
The related literature was extensively reviewed and analyzed. The recent and experiments and clinical studies on the role of ADSCs in skin scar prevention and treatment, and the possible mechanisms and biomaterials to optimize the effect of ADSCs were summarized.
RESULTS
As demonstrated by experiments and clinical studies, ADSCs participate in the whole process of skin wound healing and may prevent and treat skin scars by reducing inflammation, promoting angiogenesis, or inhibiting (muscle) fibroblasts activity to reduce collagen deposition through the p38/mitogen-activated protein kinase, peroxisome proliferator activated receptor γ, transforming growth factor β /Smads pathways. Moreover, bioengineered materials such as hydrogel from acellular porcine adipose tissue, porcine small-intestine submucosa, and poly (3-hydroxybutyrate-co-hydroxyvalerate) scaffold may further enhance the efficacy of ADSCs in preventing and treating skin scars.
CONCLUSION
Remarkable progress has been made in the application of ADSCs in skin scar prevention and treatment. While, further studies are still needed to explore the application methods of ADSCs in the clinic.
目的
综述脂肪来源干细胞（ADSCs）在皮肤瘢痕防治中的研究进展。
方法
广泛查阅并分析相关文献。总结近期关于ADSCs在皮肤瘢痕防治中作用的实验及临床研究，以及优化ADSCs作用效果的可能机制和生物材料。
结果
实验及临床研究表明，ADSCs参与皮肤伤口愈合全过程，可能通过p38/丝裂原活化蛋白激酶、过氧化物酶体增殖物激活受体γ、转化生长因子β/Smads信号通路减轻炎症、促进血管生成或抑制（肌）成纤维细胞活性以减少胶原蛋白沉积，从而防治皮肤瘢痕。此外，脱细胞猪脂肪组织水凝胶、猪小肠黏膜下层、聚（3-羟基丁酸酯-co-羟基戊酸酯）支架等生物工程材料可进一步增强ADSCs防治皮肤瘢痕的疗效。
结论
ADSCs在皮肤瘢痕防治中的应用已取得显著进展。然而，仍需进一步研究探索ADSCs在临床上的应用方法。
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