毛囊及相关干细胞在无瘢痕伤口愈合中的研究进展
[Research progress of hair follicle and related stem cells in scar-free wound healing].
作者信息
Zhou Zhentao, Zhao Qinyuan, Zhao Jun, Zhang Jufang
机构信息
The Fourth Clinical College of Zhejiang Chinese Medicine University, Hangzhou Zhejiang, 310013, P.R.China.
Department of Plastic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou Zhejiang, 310006, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Feb 15;35(2):241-245. doi: 10.7507/1002-1892.202005086.
OBJECTIVE
To explore the research progress of hair follicle and related stem cells in scar-free skin healing in recent years.
METHODS
The literature related to hair follicle and related stem cells, wound healing, and scar formation in recent years was extensively reviewed and summarized from the aspects of cell function and molecular mechanism.
RESULTS
Scar tissue after wound healing treated with hair follicle transplantation and related stem cell therapy is more mild or even without scar formation. The cell types and molecular mechanisms of the above phenomena are complex, and the bone morphogenetic protein signal transduction pathway and Wnt signal transduction pathway are strongly correlated.
CONCLUSION
The research of hair follicle and related stem cells in scar-free skin healing is at the initial stage at present. Strengthening the mechanism research may provide new ideas for the treatment of wound and scar.
目的
探讨近年来毛囊及相关干细胞在无瘢痕皮肤愈合方面的研究进展。
方法
从细胞功能和分子机制等方面，广泛查阅并总结近年来与毛囊及相关干细胞、伤口愈合和瘢痕形成相关的文献。
结果
采用毛囊移植及相关干细胞疗法治疗后的伤口愈合瘢痕组织更轻微，甚至无瘢痕形成。上述现象的细胞类型和分子机制较为复杂，骨形态发生蛋白信号转导通路和Wnt信号转导通路与之密切相关。
结论
目前毛囊及相关干细胞在无瘢痕皮肤愈合方面的研究尚处于初期阶段。加强机制研究可能为伤口和瘢痕的治疗提供新思路。
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