• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

电子束辐照灭菌聚甲基丙烯酸甲酯的物理化学和生物学方面。

Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects.

机构信息

Disruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.

Department of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, 0424, Norway.

出版信息

Macromol Biosci. 2021 Apr;21(4):e2000379. doi: 10.1002/mabi.202000379. Epub 2021 Feb 24.

DOI:10.1002/mabi.202000379
PMID:33624923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8147572/
Abstract

Electron beam (E-beam) irradiation is an attractive and efficient method for sterilizing clinically implantable medical devices made of natural and/or synthetic materials such as poly(methyl methacrylate) (PMMA). As ionizing irradiation can affect the physicochemical properties of PMMA, understanding the consequences of E-beam sterilization on the intrinsic properties of PMMA is vital for clinical implementation. A detailed assessment of the chemical, optical, mechanical, morphological, and biological properties of medical-grade PMMA after E-beam sterilization at 25 and 50 kiloGray (kGy) is reported. Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry studies indicate that E-beam irradiation has minimal effect on the chemical properties of the PMMA at these doses. While 25 kGy irradiation does not alter the mechanical and optical properties of the PMMA, 50 kGy reduces the flexural strength and transparency by 10% and 2%, respectively. Atomic force microscopy demonstrates that E-beam irradiation reduces the surface roughness of PMMA in a dose dependent manner. Live-Dead, AlamarBlue, immunocytochemistry, and complement activation studies show that E-beam irradiation up to 50 kGy has no adverse effect on the biocompatibility of the PMMA. These findings suggest that E-beam irradiation at 25 kGy may be a safe and efficient alternative for PMMA sterilization.

摘要

电子束（E-beam）辐照是一种有吸引力且有效的方法，可用于对天然和/或合成材料（如聚甲基丙烯酸甲酯（PMMA））制成的临床可植入医疗器械进行灭菌。由于电离辐照会影响 PMMA 的物理化学性质，因此了解 E 束灭菌对 PMMA 固有特性的影响对于临床应用至关重要。本文详细评估了医用级 PMMA 在 25 和 50 千戈瑞（kGy）电子束灭菌后的化学、光学、机械、形态和生物学性能。傅里叶变换红外光谱、热重分析和差示扫描量热法研究表明，在这些剂量下，电子束辐照对 PMMA 的化学性质几乎没有影响。虽然 25 kGy 的辐照不会改变 PMMA 的机械和光学性能，但 50 kGy 会使 PMMA 的弯曲强度和透明度分别降低 10%和 2%。原子力显微镜表明，电子束辐照会以剂量依赖的方式降低 PMMA 的表面粗糙度。活死、AlamarBlue、免疫细胞化学和补体激活研究表明，E 束辐照高达 50 kGy 对 PMMA 的生物相容性没有不良影响。这些发现表明，25 kGy 的电子束辐照可能是 PMMA 灭菌的一种安全有效的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/afb26d4ccadb/nihms-1695185-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/00ed3036a35e/nihms-1695185-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/2cca696bce07/nihms-1695185-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/8dba0285f3df/nihms-1695185-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/d0eb43c3383f/nihms-1695185-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/f57109faa555/nihms-1695185-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/d6a9f9bc15ab/nihms-1695185-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/76bc3d49ff10/nihms-1695185-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/afb26d4ccadb/nihms-1695185-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/00ed3036a35e/nihms-1695185-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/2cca696bce07/nihms-1695185-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/8dba0285f3df/nihms-1695185-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/d0eb43c3383f/nihms-1695185-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/f57109faa555/nihms-1695185-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/d6a9f9bc15ab/nihms-1695185-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/76bc3d49ff10/nihms-1695185-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be8f/8147572/afb26d4ccadb/nihms-1695185-f0008.jpg

相似文献

1
Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects.电子束辐照灭菌聚甲基丙烯酸甲酯的物理化学和生物学方面。
Macromol Biosci. 2021 Apr;21(4):e2000379. doi: 10.1002/mabi.202000379. Epub 2021 Feb 24.
2
Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices.消毒对基于聚甲基丙烯酸甲酯的个性化医疗器械机械性能的影响。
J Mech Behav Biomed Mater. 2018 May;81:168-172. doi: 10.1016/j.jmbbm.2018.01.033. Epub 2018 Jan 31.
3
Modification of surface characteristics of ophthalmic biomaterial-polymethyl methacrylate induced by cobalt 60 gamma irradiation.钴 60γ 射线辐照对眼科生物材料-聚甲基丙烯酸甲酯表面特性的修饰。
PLoS One. 2023 Sep 15;18(9):e0291344. doi: 10.1371/journal.pone.0291344. eCollection 2023.
4
[Viability of murine 3T3 fibroblasts on the poly(methyl methacrylate) surface modified by constant UV irradiation].[经持续紫外线照射改性的聚甲基丙烯酸甲酯表面上小鼠3T3成纤维细胞的活力]
Polim Med. 2007;37(3):13-9.
5
Critical media attributes in E-beam sterilization of corneal tissue.电子束辐照角膜组织的关键介质属性。
Acta Biomater. 2022 Jan 15;138:218-227. doi: 10.1016/j.actbio.2021.10.033. Epub 2021 Oct 28.
6
Effect of gamma, ethylene oxide, electron beam, and plasma sterilization on the behaviour of SR-PLLA fibres in vitro.γ射线、环氧乙烷、电子束和等离子体灭菌对SR-PLLA纤维体外行为的影响。
J Biomater Sci Polym Ed. 2002;13(12):1325-36. doi: 10.1163/15685620260449723.
7
Gamma sterilization of collagen/hydroxyapatite composites: Validation and radiation effects.胶原/羟基磷灰石复合材料的γ射线灭菌：验证和辐射效应。
Appl Radiat Isot. 2021 Aug;174:109758. doi: 10.1016/j.apradiso.2021.109758. Epub 2021 May 1.
8
Improving the practicality and safety of artificial corneas: Pre-assembly and gamma-rays sterilization of the Boston Keratoprosthesis.提高人工角膜的实用性和安全性：Boston 角膜假体的预组装和伽马射线灭菌。
Ocul Surf. 2018 Jul;16(3):322-330. doi: 10.1016/j.jtos.2018.04.002. Epub 2018 Apr 5.
9
Sterilization of Semiconductive Nanomaterials: The Case of Water-Suspended Poly-3-Hexylthiophene Nanoparticles.半导体纳米材料的灭菌：以水悬浮聚-3-己基噻吩纳米颗粒为例。
Adv Healthc Mater. 2021 Mar;10(6):e2001306. doi: 10.1002/adhm.202001306. Epub 2021 Jan 14.
10
Toward electron-beam sterilization of a pre-assembled Boston keratoprosthesis.针对预组装的 Boston 角膜假体的电子束灭菌。
Ocul Surf. 2021 Apr;20:176-184. doi: 10.1016/j.jtos.2021.02.009. Epub 2021 Mar 3.

引用本文的文献

1
Hydrogel Foams Containing Superabsorbent Particles for Wound Care Applications.用于伤口护理的含高吸水性颗粒的水凝胶泡沫材料。
ACS Appl Bio Mater. 2025 Jun 16;8(6):4633-4646. doi: 10.1021/acsabm.4c01719. Epub 2025 May 23.
2
The Effect of Sterilization Methods on the Mechanical Properties of 3D-Printed and Conventional PMMA Materials for Denture Bases of Immediate Obturators.灭菌方法对即刻阻塞器义齿基托用3D打印及传统聚甲基丙烯酸甲酯材料力学性能的影响
Polymers (Basel). 2025 May 7;17(9):1279. doi: 10.3390/polym17091279.
3
Effects of beta and gamma radiation sterilization on growth factor-loaded nanoparticles: an innovative approach for osteoarticular disorders treatment.

本文引用的文献

1
Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility.在聚甲基丙烯酸甲酯上溅射沉积钛可增强角膜生物相容性。
Transl Vis Sci Technol. 2020 Dec 23;9(13):41. doi: 10.1167/tvst.9.13.41. eCollection 2020 Dec.
2
Polymerization Reactions and Modifications of Polymers by Ionizing Radiation.聚合反应及聚合物的电离辐射改性
Polymers (Basel). 2020 Nov 30;12(12):2877. doi: 10.3390/polym12122877.
3
Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.
β和γ辐射灭菌对负载生长因子的纳米颗粒的影响：一种治疗骨关节疾病的创新方法。
Drug Deliv Transl Res. 2025 Mar 11. doi: 10.1007/s13346-025-01829-5.
4
Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications.适用于3D打印中光固化成型的生物材料：特性与医学应用
J Funct Biomater. 2023 Dec 22;15(1):7. doi: 10.3390/jfb15010007.
5
Electrospun-Reinforced Suturable Biodegradable Artificial Cornea.静电纺丝增强可缝合可降解人工角膜。
ACS Appl Bio Mater. 2022 Dec 19;5(12):5716-5727. doi: 10.1021/acsabm.2c00751. Epub 2022 Nov 23.
6
Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering.石墨烯内衬多孔甲基丙烯酸缩水甘油酯明胶水凝胶：对组织工程的启示
ACS Appl Nano Mater. 2021 Nov 26;4(11):12650-12662. doi: 10.1021/acsanm.1c03201. Epub 2021 Nov 10.
7
Systematic optimization of visible light-induced crosslinking conditions of gelatin methacryloyl (GelMA).系统优化明胶甲基丙烯酰（GelMA）的可见光交联条件。
Sci Rep. 2021 Dec 2;11(1):23276. doi: 10.1038/s41598-021-02830-x.
8
Critical media attributes in E-beam sterilization of corneal tissue.电子束辐照角膜组织的关键介质属性。
Acta Biomater. 2022 Jan 15;138:218-227. doi: 10.1016/j.actbio.2021.10.033. Epub 2021 Oct 28.
9
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications.将基于明胶的水凝胶用于生物粘附性眼组织工程应用的优化。
Bioact Mater. 2021 Apr 17;6(11):3947-3961. doi: 10.1016/j.bioactmat.2021.03.042. eCollection 2021 Nov.
10
Toward electron-beam sterilization of a pre-assembled Boston keratoprosthesis.针对预组装的 Boston 角膜假体的电子束灭菌。
Ocul Surf. 2021 Apr;20:176-184. doi: 10.1016/j.jtos.2021.02.009. Epub 2021 Mar 3.
中波紫外线可引起 Fuchs 内皮角膜营养不良的 DNA 损伤和雌激素-DNA 加合物，导致女性受影响更大。
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):573-583. doi: 10.1073/pnas.1912546116. Epub 2019 Dec 18.
4
Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts.γ 射线辐射灭菌对脱细胞角膜异种移植物结构和生物学特性的影响。
Acta Biomater. 2019 Sep 15;96:330-344. doi: 10.1016/j.actbio.2019.07.002. Epub 2019 Jul 5.
5
Methyl methacrylate in external fixation of supracondylar humerus fractures: An experimental study.甲基丙烯酸甲酯在上髁肱骨骨折外固定中的应用：一项实验研究。
Proc Inst Mech Eng H. 2018 Oct;232(10):1025-1029. doi: 10.1177/0954411918796533. Epub 2018 Aug 24.
6
Improving the practicality and safety of artificial corneas: Pre-assembly and gamma-rays sterilization of the Boston Keratoprosthesis.提高人工角膜的实用性和安全性：Boston 角膜假体的预组装和伽马射线灭菌。
Ocul Surf. 2018 Jul;16(3):322-330. doi: 10.1016/j.jtos.2018.04.002. Epub 2018 Apr 5.
7
Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices.消毒对基于聚甲基丙烯酸甲酯的个性化医疗器械机械性能的影响。
J Mech Behav Biomed Mater. 2018 May;81:168-172. doi: 10.1016/j.jmbbm.2018.01.033. Epub 2018 Jan 31.
8
Live-cell biosensor for assessment of adhesion qualities of biomaterials.用于评估生物材料粘附特性的活细胞生物传感器。
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:230-238. doi: 10.1016/j.msec.2017.04.071. Epub 2017 Apr 17.
9
Properties of nanofiller-loaded poly (methyl methacrylate) bone cement composites for orthopedic applications: a review.用于骨科应用的纳米填料负载聚甲基丙烯酸甲酯骨水泥复合材料的性能：综述
J Biomed Mater Res B Appl Biomater. 2017 Jul;105(5):1260-1284. doi: 10.1002/jbm.b.33643. Epub 2016 Mar 10.
10
Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines.对培养的贴壁细胞系汇合度进行非侵入性和非破坏性测量。
MethodsX. 2014 Nov 25;2:8-13. doi: 10.1016/j.mex.2014.11.002. eCollection 2015.