Tianjin Key Laboratory for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin 300350, China.
Research Center for Human Tissue and Organs Degeneration, Institute Biomedical and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
J Mater Chem B. 2021 Mar 17;9(10):2394-2406. doi: 10.1039/d1tb00184a.
Although clay-based nanocomposite hydrogels have been widely explored, their instability in hot water and saline solution inhibits their applications in biomedical engineering, and the exploration of clay-based nanocomposite hydrogels in bone defect repair is even less. In this work, we developed a stable clay-based nanocomposite hydrogel using 4-acryloylmorpholine as the monomer. After UV light illumination, the obtained poly(4-acryloylmorpholine) clay-based nanocomposite hydrogel (poly(4-acry)-clay nanocomposite hydrogel) exhibits excellent mechanical properties due to the hydrogen bond interactions between the poly(4-acryloylmorpholine) chains and the physical crosslinking effect of the nanoclay. Besides good biocompatibility, the sustainable release of intrinsic Mg2+ and Si4+ from the poly(4-acry)-clay nanocomposite hydrogel endows the system with excellent ability to promote the osteogenic differentiation of primary rat osteoblasts (ROBs) and can promote new bone formation effectively after implantation. We anticipate that these kinds of clay-based nanocomposite hydrogels with sustained release of bioactive ions will open a new avenue for the development of novel biomaterials for bone regeneration.
尽管粘土基纳米复合水凝胶已经得到了广泛的研究，但它们在热水和盐溶液中的不稳定性限制了它们在生物医学工程中的应用，而在骨缺损修复中对粘土基纳米复合水凝胶的探索就更少了。在这项工作中，我们使用 4-丙烯酰吗啉作为单体开发了一种稳定的粘土基纳米复合水凝胶。在紫外光照射下，得到的聚（4-丙烯酰吗啉）粘土基纳米复合水凝胶（聚（4-丙烯酰）-粘土纳米复合水凝胶）由于聚（4-丙烯酰吗啉）链之间的氢键相互作用和纳米粘土的物理交联效应，表现出优异的机械性能。除了良好的生物相容性外，聚（4-丙烯酰）-粘土纳米复合水凝胶中固有 Mg2+和 Si4+的持续释放赋予该系统促进原代大鼠成骨细胞（ROBs）成骨分化的优异能力，并能在植入后有效促进新骨形成。我们预计，这些具有生物活性离子持续释放功能的粘土基纳米复合水凝胶将为新型骨再生生物材料的开发开辟新途径。
