Guo Wendi, Dong Hongbin, Wang Xing
Department of Prosthodontics and Implant Dentistry, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Affiliated Stomatological Hospital of Xinjiang Medical University, Urumqi, China.
Front Bioeng Biotechnol. 2024 Apr 24;12:1380528. doi: 10.3389/fbioe.2024.1380528. eCollection 2024.
Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.
牙周病是最常见的口腔疾病类型。牙周骨缺损是晚期牙周病的临床后果，严重影响患者的生活质量。促进牙周组织再生和修复牙周骨缺损是牙周病的最终治疗目标，但手段和方法非常有限。水凝胶是一类高度亲水的聚合物网络，其良好的生物相容性使其近年来成为口腔医学领域热门的研究材料。本文综述了水凝胶的当前主流类型和特点，总结了近年来水凝胶在促进牙周组织再生和骨缺损修复方面的相关基础研究。深入探讨了可能的作用机制和疗效评估，并对应用前景也进行了讨论。
