Tipa Cezar, Cidade Maria T, Borges João P, Costa Luis C, Silva Jorge C, Soares Paula I P
CENIMAT|i3N, Department of Materials Science, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal.
I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Nanomaterials (Basel). 2022 Sep 23;12(19):3308. doi: 10.3390/nano12193308.
In recent decades, new and improved materials have been developed with a significant interest in three-dimensional (3D) scaffolds that can cope with the diverse needs of the expanding biomedical field and promote the required biological response in multiple applications. Due to their biocompatibility, ability to encapsulate and deliver drugs, and capacity to mimic the extracellular matrix (ECM), typical hydrogels have been extensively investigated in the biomedical and biotechnological fields. The major limitations of hydrogels include poor mechanical integrity and limited cell interaction, restricting their broad applicability. To overcome these limitations, an emerging approach, aimed at the generation of hybrid materials with synergistic effects, is focused on incorporating nanoparticles (NPs) within polymeric gels to achieve nanocomposites with tailored functionality and improved properties. This review focuses on the unique contributions of clay nanoparticles, regarding the recent developments of clay-based nanocomposite hydrogels, with an emphasis on biomedical applications.
近几十年来，人们开发出了新型且改良的材料，对三维（3D）支架产生了浓厚兴趣，这种支架能够满足不断发展的生物医学领域的各种需求，并在多种应用中促进所需的生物反应。由于其生物相容性、封装和递送药物的能力以及模拟细胞外基质（ECM）的能力，典型的水凝胶已在生物医学和生物技术领域得到广泛研究。水凝胶的主要局限性包括机械完整性差和细胞相互作用有限，这限制了它们的广泛应用。为了克服这些局限性，一种旨在生成具有协同效应的杂化材料的新兴方法，专注于将纳米颗粒（NPs）掺入聚合物凝胶中，以实现具有定制功能和改进性能的纳米复合材料。本综述重点关注粘土纳米颗粒的独特贡献，涉及基于粘土的纳米复合水凝胶的最新进展，尤其侧重于生物医学应用。
