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P53-mediated in vitro inhibition of PhIP-induced oxidative damage by myricetin bulk and nano forms in healthy lymphocytes.

作者信息

Akhtar Shabana, Anderson Diana, Azam Talha Muhammad, Malik Arif

机构信息

Institute of Molecular Biology and Biotechnology (IMBB) and Centre for Research in Molecular Medicine (CRiMM), University of Lahore, Defence road campus, Lahore, Pakistan.

School of Chemistry and Biosciences, University of Bradford, Bradford, BD7-1DP, UK.

出版信息

Arch Toxicol. 2021 May;95(5):1853-1856. doi: 10.1007/s00204-021-03010-6. Epub 2021 Feb 24.

DOI:10.1007/s00204-021-03010-6
PMID:33625525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8113169/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f263/8113169/fc2fb116e519/204_2021_3010_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f263/8113169/5338481ffacf/204_2021_3010_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f263/8113169/fc2fb116e519/204_2021_3010_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f263/8113169/5338481ffacf/204_2021_3010_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f263/8113169/fc2fb116e519/204_2021_3010_Fig2_HTML.jpg

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本文引用的文献

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Arch Toxicol. 2021 Jan;95(1):337-343. doi: 10.1007/s00204-020-02938-5. Epub 2020 Oct 30.
2
An in vitro investigation into the protective and genotoxic effects of myricetin bulk and nano forms in lymphocytes of MGUS patients and healthy individuals.体外研究表没食子儿茶素没食子酸酯原药和纳米形式对 MGUS 患者和健康个体淋巴细胞的保护作用和遗传毒性。
Toxicol Lett. 2020 Jul 1;327:33-40. doi: 10.1016/j.toxlet.2020.03.012. Epub 2020 Mar 24.
3
Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.
突变型 p53 相关的 ROS 调控在癌细胞中的分子机制。
Biomolecules. 2020 Feb 26;10(3):361. doi: 10.3390/biom10030361.
4
In-Vitro Anti-Proliferative, Apoptotic and Antioxidative Activities of Medicinal Herb Kalonji (Nigella sativa).药用植物黑种草（Nigella sativa）的体外抗增殖、凋亡和抗氧化活性。
Curr Pharm Biotechnol. 2019;20(15):1288-1308. doi: 10.2174/1389201020666190821144633.
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ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.JNK依赖活性氧（ROS）的激活将p53转化为一种有效的癌基因抑制剂，从而导致强烈的细胞凋亡。
Cell Death Differ. 2014 Apr;21(4):612-23. doi: 10.1038/cdd.2013.186. Epub 2014 Jan 10.
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Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: Protection by taurine.叔丁基过氧化氢诱导小鼠红细胞氧化损伤：牛磺酸的保护作用。
Pathophysiology. 2012 Apr;19(2):137-48. doi: 10.1016/j.pathophys.2012.05.001. Epub 2012 May 22.
7
The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients.黄酮类化合物对食物诱变剂诱导的结肠癌患者外周血淋巴细胞 DNA 损伤的保护作用。
Food Chem Toxicol. 2012 Feb;50(2):124-9. doi: 10.1016/j.fct.2011.08.020. Epub 2011 Sep 1.
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Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders.精神疾病患者死后前额皮质中主要的大脑抗氧化剂谷胱甘肽水平降低。
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