Division of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
J Autism Dev Disord. 2022 Jan;52(1):52-60. doi: 10.1007/s10803-021-04921-0. Epub 2021 Feb 24.
We analyzed claims data from the Taiwan National Health Insurance database, which contains data of 23.5 million Taiwan residents. We included children born after January 1, 2000 who had received a diagnosis of autism spectrum disorders (ASD). Patients who were not diagnosed with ASD were included in the control group. The ASD prevalence was 517 in 62,051 (0.83%) children. Neonatal jaundice, hypoglycemia, intrauterine growth retardation (IUGR), and craniofacial anomalies (CFA) differed significantly between the ASD and control groups. After logistic regressive analysis, the adjusted odds ratios of IUGR, CFA, neonatal hypoglycemia, and neonatal jaundice were 8.58, 7.37, 3.83, and 1.32, respectively. Those insidiously perinatal risk factors, namely CFA, IUGR, neonatal hypoglycemia, and neonatal jaundice, could increase the risk of ASD.
我们分析了来自台湾全民健康保险数据库的理赔数据，该数据库包含了 2350 万台湾居民的数据。我们纳入了 2000 年 1 月 1 日后出生、被诊断为自闭症谱系障碍（ASD）的儿童。未被诊断为 ASD 的患者被纳入对照组。ASD 的患病率为 62051 名儿童中的 517 名（0.83%）。新生儿黄疸、低血糖、宫内生长迟缓（IUGR）和颅面畸形（CFA）在 ASD 组和对照组之间差异显著。经过逻辑回归分析，IUGR、CFA、新生儿低血糖和新生儿黄疸的校正比值比分别为 8.58、7.37、3.83 和 1.32。那些隐匿性围产期危险因素，即 CFA、IUGR、新生儿低血糖和新生儿黄疸，可能会增加 ASD 的风险。
