Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12A, 171 77, Stockholm, Sweden.
Erasmus School of Social and Behavioural Sciences Erasmus School of Social and Behavioural Sciences/ Behavioural Change, Burg. Oudlaan 50, Rotterdam, The Netherlands.
J Autism Dev Disord. 2023 May;53(5):1906-1914. doi: 10.1007/s10803-022-05466-6. Epub 2022 Feb 7.
Pre- and post-term children show increased autism risk. Little is known about gestational age (GA) prevalence among autistic children, and their respective autism phenotype. We compared prevalence of pre-, full- and post-term birth between a population-derived sample of N = 606 (137 females, 22.61%) autistic children and adolescents (mean age = 14.01, SD = 3.63, range 3-24) from the Netherlands Autism Register, and matched controls from the Dutch birth register. Autism phenotype and comorbid symptoms were assessed with the AQ-short and SDQ questionnaires. Using logistic regression, we found higher prevalence of pre- and post-term birth among autistic individuals but no phenotypical differences across GA groups. Autism risk was particularly elevated for post-term children, highlighting the need for closer investigation of autism on the whole GA range.
早产儿和足月儿患自闭症的风险增加。目前对于自闭症儿童的胎龄（GA）流行率以及他们各自的自闭症表型知之甚少。我们比较了荷兰自闭症登记处的一个人群样本中的 606 名（137 名女性，22.61%）自闭症儿童和青少年（平均年龄=14.01，SD=3.63，范围 3-24）和来自荷兰出生登记处的匹配对照组之间的早产、足月和过期产的发生率。使用 AQ 短问卷和 SDQ 问卷评估自闭症表型和合并症状。使用逻辑回归，我们发现自闭症个体中早产和过期产的发生率较高，但 GA 组之间没有表型差异。过期产儿童的自闭症风险特别高，这突出表明需要在整个 GA 范围内更密切地研究自闭症。
