Jackson M R, Mayhew T M, Haas J D
Department of Anatomy, Marischal College, University of Aberdeen, UK.
Placenta. 1988 Jan-Feb;9(1):1-8. doi: 10.1016/0143-4004(88)90067-7.
Sections of human term placentae delivered at low and high altitude to indigenous and non-indigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indices of thickness variation. No significant ethnic, sex or interaction effects were found. At high altitude, the villous membrane was significantly more variable in thickness owing to a lower harmonic mean but the same arithmetic mean thickness. Alterations in the arithmetic and harmonic mean thicknesses of the trophoblast contributed to the thinning of the villous membrane. The trophoblast was thinner and more irregular in thickness at high altitude. These findings are discussed in the context of placental diffusing capacity and the possible mechanisms for formation of vasculosyncytial membranes.
采用体视学方法分析了在玻利维亚低海拔和高海拔地区分别分娩给当地居民和非当地居民的足月人胎盘切片。获得了绒毛膜和滋养层的算术平均厚度和调和平均厚度的估计值。然后用这些值得出厚度变化指数。未发现显著的种族、性别或交互作用效应。在高海拔地区，由于调和平均厚度较低但算术平均厚度相同，绒毛膜厚度的变异性显著更大。滋养层算术平均厚度和调和平均厚度的改变导致了绒毛膜变薄。在高海拔地区，滋养层更薄且厚度更不规则。结合胎盘扩散能力和血管合体膜形成的可能机制对这些发现进行了讨论。
