Ali K Z
Anatomy Department, College of Medicine, King Saud University, Abha Branch, Saudi Arabia.
Placenta. 1997 Jul-Aug;18(5-6):447-50. doi: 10.1016/s0143-4004(97)80046-x.
Paraffin-embedded histological material was examined from 10 placentae from uncomplicated pregnancies at high altitude (3000 m). This was compared with material from 10 placentae delivered at low altitude (500 m). The sample groups were matched for maternal age, gestational age and parity. Within terminal and intermediate villi the volume-weighted mean cytotrophoblast cell volume did not significantly change at high altitude (754.1 microm3 at low altitude versus 796 microm3 at high altitude). The fractional volume of the villi occupied by cytotrophoblastic cells and their nuclei number per 10000 microm3 of villous tissue were significantly greater in placenta from high altitude (3.17 and 1.86 per cent, respectively) than those from low altitude (1.05 and 0.79 per cent, respectively) (P<0.0004 and P<0.0058, respectively). No significant differences in either fractional volume of the syncytiotrophoblast or its nuclei number per 10000 microm3 of villous tissue were observed between placentae from high (26.01 and 11.6 per cent, respectively) and low altitude (26.33 and 11.89 per cent, respectively). These results suggest an increase in the number of cytotrophoblastic cells at high altitudes without any changes in their volume. Exposure to hypobaric hypoxia is thought to be the principal aetiological factor.
对来自高海拔地区（3000米）10例无并发症妊娠胎盘的石蜡包埋组织学材料进行了检查。并与来自低海拔地区（500米）的10例胎盘材料进行了比较。样本组在产妇年龄、孕周和产次方面进行了匹配。在终末绒毛和中间绒毛内，体积加权平均细胞滋养层细胞体积在高海拔地区没有显著变化（低海拔地区为754.1立方微米，高海拔地区为796立方微米）。高海拔地区胎盘的细胞滋养层细胞占据绒毛的分数体积及其每10000立方微米绒毛组织的细胞核数量显著高于低海拔地区（分别为3.17%和1.86%）（低海拔地区分别为1.05%和0.79%）（P分别<0.0004和P<0.0058）。在高海拔地区（分别为26.01%和11.6%）和低海拔地区（分别为26.33%和11.89%）的胎盘之间，合体滋养层的分数体积或其每10000立方微米绒毛组织的细胞核数量均未观察到显著差异。这些结果表明，高海拔地区细胞滋养层细胞数量增加，但其体积没有任何变化。低氧性缺氧被认为是主要的病因因素。
