Nie Xiaomin, Xu Yiting, Shen Yun, Wang Yufei, Ma Xiaojing, Bao Yuqian
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Int J Endocrinol. 2021 Feb 5;2021:6624516. doi: 10.1155/2021/6624516. eCollection 2021.
Previous studies found that thyroid hormones stimulate osteoblast-like cells to secrete osteocalcin. We aimed to investigate the association between serum thyroid hormone and serum osteocalcin in euthyroid population. The study recruited 1152 community-based euthyroid subjects (average age 59 ± 8 years), among whom 677 were women. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and osteocalcin were measured by electrochemiluminescence immunoassays. After adjusting for age and gender, partial correlation analysis showed that FT3 and FT3/FT4 were both positively correlated with body mass index (BMI) and serum osteocalcin levels (all < 0.05) and BMI was negatively correlated with serum osteocalcin levels ( < 0.01), while FT4 and TSH were not correlated with serum osteocalcin levels (all > 0.05). Age, gender, blood pressure, thyroid hormones, and multiple metabolic risk factors were included in the ridge regression model. FT3 and FT3/FT4 were independently and positively associated with serum osteocalcin levels (all < 0.05), while BMI was independently and negatively associated with serum osteocalcin levels ( < 0.01). The mediating effect model showed that FT3 and FT3/FT4 suppressed the negative association between BMI and serum osteocalcin levels, with suppressing effects of 6.41% and 10.39%, respectively. In euthyroid subjects, both FT3 and FT3/FT4 were positively associated with serum osteocalcin levels, and they further suppressed the negative association between BMI and serum osteocalcin levels.
以往研究发现，甲状腺激素可刺激成骨样细胞分泌骨钙素。我们旨在研究甲状腺功能正常人群中血清甲状腺激素与血清骨钙素之间的关联。该研究招募了1152名社区甲状腺功能正常的受试者（平均年龄59±8岁），其中677名是女性。采用电化学发光免疫分析法测定血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和骨钙素。在调整年龄和性别后，偏相关分析显示，FT3和FT3/FT4均与体重指数（BMI）和血清骨钙素水平呈正相关（均P<0.05），而BMI与血清骨钙素水平呈负相关（P<0.01），而FT4和TSH与血清骨钙素水平无相关性（均P>0.05）。年龄、性别、血压、甲状腺激素和多种代谢危险因素被纳入岭回归模型。FT3和FT3/FT4与血清骨钙素水平独立正相关（均P<0.05），而BMI与血清骨钙素水平独立负相关（P<0.01）。中介效应模型显示，FT3和FT3/FT4抑制了BMI与血清骨钙素水平之间的负相关，抑制效应分别为6.41%和10.39%。在甲状腺功能正常的受试者中，FT3和FT3/FT4均与血清骨钙素水平呈正相关，且它们进一步抑制了BMI与血清骨钙素水平之间的负相关。
