柚皮苷治疗对去卵巢大鼠绝经后骨质疏松症的影响：一项Meta分析和系统评价
Effect of Naringin Treatment on Postmenopausal Osteoporosis in Ovariectomized Rats: A Meta-Analysis and Systematic Review.
作者信息
Zhu Zhu, Xie Wenjing, Li Yanyan, Zhu Zaiou, Zhang Wei
机构信息
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Oral Special Consultation, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
出版信息
Evid Based Complement Alternat Med. 2021 Feb 10;2021:6016874. doi: 10.1155/2021/6016874. eCollection 2021.
BACKGROUND
Osteoporosis is a major disease that affects the quality of life of middle-aged and old people, so it is very important to find efficient and safe drugs to treat osteoporosis. The purpose of this study was to investigate the therapeutic effect of naringin on postmenopausal osteoporosis in ovariectomized (OVX) rats.
METHODS
Chinese biomedical databases, CNKI, PubMed, EMBASE, and Wan Fang were searched for articles from inception to March 2020. Two independent researchers screened articles according to inclusion criteria. RevMan 5.3 was used for data analysis.
RESULTS
Ten studies were included in the systematic review. The bone mineral density (BMD) significantly increased after naringin treatment (weighted mean difference, 0.06; 95% CI, 0.03-0.09; < 0.01). There was no significant increase in BMD after estrogen treatment compared with naringin (weighted mean difference, 0.00; 95% CI, -0.00 to 0.01; = 0.06). The trabecular bone volume (BV/TV) (weighted mean difference, 2.09; 95% CI, 1.85-2.34; < 0.01) and trabecular thickness (Tb.Th) (weighted mean difference, 6.65; 95% CI, 6.55-6.74; < 0.01) significantly increased after using naringin.
CONCLUSIONS
Naringin had been shown to promote bone formation in OVX rats. However, the mechanism of naringin needs more research to confirm.
背景
骨质疏松症是一种影响中老年人群生活质量的主要疾病，因此寻找高效且安全的治疗骨质疏松症的药物非常重要。本研究旨在探讨柚皮苷对去卵巢（OVX）大鼠绝经后骨质疏松症的治疗效果。
方法
检索中国生物医学数据库、知网、PubMed、EMBASE和万方数据库，查找从建库至2020年3月的文章。两名独立研究人员根据纳入标准筛选文章。使用RevMan 5.3进行数据分析。
结果
系统评价纳入了10项研究。柚皮苷治疗后骨密度（BMD）显著增加（加权平均差，0.06；95%置信区间，0.03 - 0.09；P < 0.01）。与柚皮苷相比，雌激素治疗后BMD无显著增加（加权平均差，0.00；95%置信区间，-0.00至0.01；P = 0.06）。使用柚皮苷后，骨小梁体积（BV/TV）（加权平均差，2.09；95%置信区间，1.85 - 2.34；P < 0.01）和骨小梁厚度（Tb.Th）（加权平均差，6.65；95%置信区间，6.55 - 6.74；P < 0.01）显著增加。
结论
已表明柚皮苷可促进OVX大鼠的骨形成。然而，柚皮苷的作用机制需要更多研究来证实。
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