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一种新型草药配方对高脂饮食诱导的肥胖小鼠的抗肥胖作用。

Antiobesity Effect of a Novel Herbal Formulation in High-Fat Diet-Induced Obese Mice.

作者信息

Choi Hak Joo, Kim Hwa Young, Park Kyoung Sik

机构信息

Food Test and Research Center, Daejeon University, Daejeon 34520, Republic of Korea.

Ju Yeong NS Co., Ltd, Seoul 05854, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2021 Feb 8;2021:6612996. doi: 10.1155/2021/6612996. eCollection 2021.

DOI:10.1155/2021/6612996
PMID:33628302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7886504/
Abstract

A variety of natural products have been explored for their antiobesity potential and widely used to develop dietary supplements for the prevention of weight gain from excess body fat. In an attempt to find a natural antiobesity agent, this study was designed to evaluate the antiobesity activity of a novel herbal formulation composed of extracts from three medicinal plants in high-fat diet- (HFD-) induced obese mice. After the thirteen-week oral administration of the test materials to mice, the body weight gain, whole-body fat mass, adipose tissue weight, and the expression levels of obesity-related proteins were measured. Our results indicated that can suppress body weight gain and lower whole-body fat mass in HFD-induced obese mice. Significant decreases in epididymal and retroperitoneal fat mass were observed in -treated groups compared with the HFD-fed control group ( < 0.05). Furthermore, the oral administration of caused significant decreases in the expression level of adipogenic (C/EBP and PPAR) and lipogenic (ACC) markers and notable increases in the production level of thermogenetic (AMPK, PGC1 and UCP1) and lipolytic (HSL) proteins. These findings suggest that holds great promise for a novel herbal formulation with antiobesity activities, preventing body fat accumulation and altering lipid metabolism.

摘要

人们已经对多种天然产物的抗肥胖潜力进行了探索，并广泛用于开发膳食补充剂，以预防因体内脂肪过多而导致的体重增加。为了寻找一种天然的抗肥胖剂，本研究旨在评估一种由三种药用植物提取物组成的新型草药制剂对高脂饮食（HFD）诱导的肥胖小鼠的抗肥胖活性。在对小鼠口服测试材料13周后，测量体重增加、全身脂肪量、脂肪组织重量以及肥胖相关蛋白的表达水平。我们的结果表明，[具体草药制剂名称未给出]可以抑制HFD诱导的肥胖小鼠的体重增加并降低全身脂肪量。与高脂饮食喂养的对照组相比，[具体草药制剂名称未给出]处理组的附睾和腹膜后脂肪量显著减少（P<0.05）。此外，口服[具体草药制剂名称未给出]导致脂肪生成（C/EBP和PPAR）和脂肪生成（ACC）标志物的表达水平显著降低，产热（AMPK、PGC1和UCP1）和脂肪分解（HSL）蛋白的产生水平显著增加。这些发现表明，[具体草药制剂名称未给出]有望成为一种具有抗肥胖活性的新型草药制剂，可预防体脂积累并改变脂质代谢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/584f80a12918/ECAM2021-6612996.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/3d63b4b2135d/ECAM2021-6612996.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/1a87492e0e1d/ECAM2021-6612996.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/1d993a12d037/ECAM2021-6612996.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/a09a2428aa38/ECAM2021-6612996.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/d8de35fd88ca/ECAM2021-6612996.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/584f80a12918/ECAM2021-6612996.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/3d63b4b2135d/ECAM2021-6612996.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/1a87492e0e1d/ECAM2021-6612996.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/1d993a12d037/ECAM2021-6612996.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/a09a2428aa38/ECAM2021-6612996.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/d8de35fd88ca/ECAM2021-6612996.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba1/7886504/584f80a12918/ECAM2021-6612996.006.jpg

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