Antiobesity Effect of a Novel Herbal Formulation in High-Fat Diet-Induced Obese Mice.

A variety of natural products have been explored for their antiobesity potential and widely used to develop dietary supplements for the prevention of weight gain from excess body fat. In an attempt to find a natural antiobesity agent, this study was designed to evaluate the antiobesity activity of a novel herbal formulation composed of extracts from three medicinal plants in high-fat diet- (HFD-) induced obese mice. After the thirteen-week oral administration of the test materials to mice, the body weight gain, whole-body fat mass, adipose tissue weight, and the expression levels of obesity-related proteins were measured. Our results indicated that can suppress body weight gain and lower whole-body fat mass in HFD-induced obese mice. Significant decreases in epididymal and retroperitoneal fat mass were observed in -treated groups compared with the HFD-fed control group ( < 0.05). Furthermore, the oral administration of caused significant decreases in the expression level of adipogenic (C/EBP and PPAR) and lipogenic (ACC) markers and notable increases in the production level of thermogenetic (AMPK, PGC1 and UCP1) and lipolytic (HSL) proteins. These findings suggest that holds great promise for a novel herbal formulation with antiobesity activities, preventing body fat accumulation and altering lipid metabolism.