Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Sinyong-Dong, Iksan 570-749, Republic of Korea.
School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Biomed Res Int. 2022 May 11;2022:9120259. doi: 10.1155/2022/9120259. eCollection 2022.
Obesity and overweight have posed a severe threat to humanity, needing urgent efforts for the development of safe and effective therapeutic interventions. In this research work, we have developed two polyherbal formulations A and B basically consisting of root powder (also called inulin of synanthrin) along with other herbs for the treatment of obesity. Evaluation of the antioxidant activity of both formulations using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging assays showed good antioxidant potentials. Both formulations A and B showed good antiobesity activity on a diet-induced obesity (DIO) model of mice by effectively lowering the body weight of mice compared to the high-fat diet (HFD) control mice, mainly by reducing the food efficiency ratio (FER). Furthermore, both formulations ameliorated lipoprotein misbalances induced by obesity and thus decreased the atherogenic index. Treatment with both formulations significantly decreased the liver and epididymal white adipose tissue (WAT) weight. This was supported by the improvement in steatosis of the liver and reduced hypertrophy in WAT on histological examination. In addition, formulations A and B have been seen as effective in controlling fasting blood glucose levels probably by alleviating HFD-induced insulin resistance. All of these results collectively suggest that formulations A and B serve as potentially safe and effective herbal interventions to control obesity and its comorbidities.
肥胖和超重对人类构成了严重威胁，需要紧急努力开发安全有效的治疗干预措施。在这项研究工作中，我们开发了两种基本由根粉（也称为蛇床子素菊粉）和其他草药组成的复方 A 和 B，用于治疗肥胖症。使用 1,1-二苯基-2-苦基肼基（DPPH）和 2,2'-联氮-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基清除测定法评估两种配方的抗氧化活性，显示出良好的抗氧化潜力。与高脂肪饮食（HFD）对照组相比，两种配方 A 和 B 在饮食诱导肥胖（DIO）小鼠模型中均表现出良好的抗肥胖活性，可有效降低小鼠体重，主要通过降低食物效率比（FER）来实现。此外，两种配方均改善了肥胖引起的脂蛋白失衡，从而降低了致动脉粥样硬化指数。两种配方的治疗均显著降低了肝脏和附睾白色脂肪组织（WAT）的重量。组织学检查显示肝脏脂肪变性改善和 WAT 肥大减轻，这支持了这一结果。此外，配方 A 和 B 似乎有效控制空腹血糖水平，可能是通过减轻 HFD 诱导的胰岛素抵抗。所有这些结果都表明，配方 A 和 B 可以作为控制肥胖及其合并症的潜在安全有效的草药干预措施。
