Zhu Tongjian, Wang Zhuo, Wang Songyun, Hu Wei, Chen Hui, Xie Jing, Wang Meng, Ma Kezhong, Jiang Hong
Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei, China.
Cardiol Res Pract. 2021 Feb 10;2021:6633948. doi: 10.1155/2021/6633948. eCollection 2021.
Circulating adiponectin has been suggested to be associated with atrial fibrillation (AF). However, whether the association differs by age and gender remains unknown. We performed a case-control study to evaluate the above association.
AF patients who underwent 24-hour long-range 12-channel electrocardiogram examination at our center were included in this study, and people with normal sinus rhythm (NSR) were included as controls. All participants underwent echocardiography and heart rate variability tests. Biochemical parameters and adiponectin levels were also evaluated. Receiver operating characteristic (ROC) analyses were used to determine the predictive efficacy of adiponectin for AF, and multivariate logistic regression analysis was performed to evaluate the potential independent predictors of AF.
Overall, 84 patients with AF and 84 people with NSR were included. Serum adiponectin was significantly higher in AF patients compared to that in controls ( < 0.001). ROC analysis showed that higher serum adiponectin (>6.098 g/mL) had predictive efficacy for AF, with an area under the curve of 0.660 (95% confidence interval [CI]: 577-0.742). The results of multivariate logistic regression analysis showed that higher adiponectin was an independent predictor of AF in the overall participants (odds ratio [OR] 1.224, 95% CI 1.018-1.471, =0.032). Subgroup analysis showed that higher adiponectin was independently associated with AF in women (OR 1.893, 95% CI 1.160-3.089, =0.011) and in patients aged < 65 years (OR 1.453, 95% CI 1.023-2.064, =0.037), but not in men or those aged ≥ 65 years.
Higher serum adiponectin level was independently associated with higher odds for AF in women and in participants <65 years old, but not in men or those aged ≥65 years.
有研究表明循环脂联素与心房颤动（AF）有关。然而，这种关联是否因年龄和性别而异仍不清楚。我们进行了一项病例对照研究来评估上述关联。
本研究纳入了在我们中心接受24小时远程12导联心电图检查的AF患者，并将窦性心律正常（NSR）的人作为对照。所有参与者均接受了超声心动图和心率变异性测试。还评估了生化参数和脂联素水平。采用受试者工作特征（ROC）分析来确定脂联素对AF的预测效能，并进行多因素逻辑回归分析以评估AF的潜在独立预测因素。
总体而言，纳入了84例AF患者和84例NSR患者。AF患者的血清脂联素水平显著高于对照组（<0.001）。ROC分析表明，较高的血清脂联素（>6.098 g/mL）对AF具有预测效能，曲线下面积为0.660（95%置信区间[CI]：577 - 0.742）。多因素逻辑回归分析结果显示，较高的脂联素是总体参与者中AF的独立预测因素（比值比[OR] 1.224，95% CI 1.018 - 1.471，=0.032）。亚组分析表明，较高的脂联素与女性AF独立相关（OR 1.893，95% CI 1.160 - 3.089，=0.011）以及年龄<65岁的患者（OR 1.453，95% CI 1.023 - 2.064，=0.037），但与男性或年龄≥65岁的患者无关。
较高的血清脂联素水平与女性及年龄<65岁参与者中AF的较高发病几率独立相关，但与男性或年龄≥65岁的患者无关。
