Sharma Roop, Gaur Ajay
Department of Paediatrics, Paediatric Critical and Intensive Care, Royal College of Paediatrics and Child Health, London, UK.
Department of Paediatrics, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior, India.
Clin Exp Vaccine Res. 2021 Jan;10(1):44-46. doi: 10.7774/cevr.2021.10.1.44. Epub 2021 Jan 31.
The purpose of this study is to study the various adverse reactions caused post measles and rubella vaccination done during measles rubella (MR) vaccine campaign in India.
Prospective, observational study was done in a government tertiary care pediatric intensive care unit. Children aged between 9 months to 15 years, who presented with adverse effects (severe enough to warrant admission) within 7 days of MR vaccine administration.
Most common presenting complaint was fever (44.8%), followed by vomiting (34.5%), abdominal pain and dizziness (31%). Abnormal body movements were noted in two children (6.8%) on first day and in one child on fifth day of vaccine administration. Two children (6.8%) presented with generalized macular rashes all over the body on 4th day after vaccination. Altered sensorium on same day of vaccine administration was the presenting symptom of one child. All children improved gradually and were discharged after few days with no mortality or long-term morbidity. Investigations were done according to the protocol of the unit; nothing came significant to be reported. Neither of the children had positive blood culture.
MR vaccination programs are scientifically sound, highly recommended and proven effective globally. Causality assessment of adverse events is still an evolving science, and despite taking all the measures and adopting all the available scientific methods, sometimes it is not possible to incontrovertibly prove the causal association of an event with a vaccine. Much more advancement in this area is needed.
本研究旨在探讨在印度麻疹风疹（MR）疫苗接种运动期间接种麻疹和风疹疫苗后引起的各种不良反应。
在一家政府三级护理儿科重症监护病房进行前瞻性观察研究。研究对象为年龄在9个月至15岁之间、在接种MR疫苗后7天内出现不良反应（严重到需要住院治疗）的儿童。
最常见的主诉是发热（44.8%），其次是呕吐（34.5%）、腹痛和头晕（31%）。两名儿童（6.8%）在接种疫苗第一天出现异常身体动作，一名儿童在接种疫苗第五天出现异常身体动作。两名儿童（6.8%）在接种疫苗后第4天全身出现全身性斑疹。一名儿童在接种疫苗当天出现意识改变作为首发症状。所有儿童均逐渐好转，几天后出院，无死亡或长期发病情况。根据科室方案进行了检查；未发现有重大情况报告。所有儿童血培养均为阴性。
MR疫苗接种计划在科学上是合理的，在全球范围内受到高度推荐且已被证明有效。不良事件的因果关系评估仍是一门不断发展的科学，尽管采取了所有措施并采用了所有可用的科学方法，但有时仍无法确凿地证明某一事件与疫苗之间的因果关联。这一领域还需要取得更大的进展。
