Shohat T, Green M S, Nakar O, Ballin A, Duvdevani P, Cohen A, Shohat M
Israel Center for Disease Control, Gertner Institute for Policy Research, Tel-Hashomer, Israel.
Isr Med Assoc J. 2000 Mar;2(3):192-5.
In trials comparing different formulations of measles vaccine, excess non-specific mortality occurred in female children who received high titer vaccine. These findings suggest a gender-specific effect of measles vaccine.
To determine whether gender differences exist in the rates of adverse reactions and morbidity in the month following immunization with measles-containing vaccine, and to evaluate whether there is a gender-specific association between the humoral immune response to measles vaccination and post-vaccination morbidity.
Parents completed questionnaires on the health status of 755 infants aged 15-20 months, during the month preceding and the month following the measles-mumps-rubella vaccination. Blood samples were tested for measles antibody titers in a subsample of 237 infants.
After controlling background morbidity in the infants, the relative risk of fever and rash following vaccination was 2.35 in females and 1.36 in males. The geometric mean antibody titers against measles were similar in both sexes and there was no significant association between antibody titer and post-vaccination morbidity in either sex.
Our findings demonstrate higher rates of adverse effects in females following vaccination with MMR vaccine, irrespective of the humoral response. This study emphasizes the need to consider possible gender differences when evaluating new vaccines.
在比较不同配方麻疹疫苗的试验中，接种高滴度疫苗的女童出现了额外的非特异性死亡。这些发现提示麻疹疫苗存在性别特异性效应。
确定接种含麻疹疫苗后一个月内不良反应和发病几率是否存在性别差异，并评估麻疹疫苗接种后的体液免疫反应与接种后发病之间是否存在性别特异性关联。
家长完成了关于755名15至20个月大婴儿在接种麻疹-腮腺炎-风疹疫苗前一个月和后一个月健康状况的问卷。对237名婴儿的子样本进行了血样麻疹抗体滴度检测。
在控制婴儿的背景发病率后，接种疫苗后发热和皮疹的相对风险在女性中为2.35，在男性中为1.36。两性针对麻疹的几何平均抗体滴度相似，且抗体滴度与两性接种后发病之间均无显著关联。
我们的研究结果表明，接种MMR疫苗后女性的不良反应发生率更高，与体液反应无关。本研究强调在评估新疫苗时需要考虑可能存在的性别差异。
