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自体脂肪移植治疗硬皮病残端皮肤溃疡：一例报告

Autologous fat grafting in the treatment of a scleroderma stump-skin ulcer: a case report.

作者信息

Giuggioli Dilia, Spinella Amelia, Cocchiara Emanuele, de Pinto Marco, Pinelli Massimo, Parenti Luca, Salvarani Carlo, De Santis Giorgio

机构信息

Scleroderma Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

出版信息

Case Reports Plast Surg Hand Surg. 2021 Feb 12;8(1):18-22. doi: 10.1080/23320885.2021.1881521.

DOI:10.1080/23320885.2021.1881521
PMID:33628864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7889081/
Abstract

Here we describe the case of a 60-year-old-woman with systemic sclerosis sent to our Scleroderma Unit to treat digital stumps. The stumps were successfully treated with autologous fat grafting (crown-shape infiltration). Our technique of autologous lipotransfer improved wound healing in a scleroderma patient with stump-digital ulcers where all other options failed.

摘要

在此，我们描述了一名60岁系统性硬化症女性患者的病例，该患者被送至我们的硬皮病治疗单元治疗手指残端。通过自体脂肪移植（冠状浸润）成功治疗了这些残端。我们的自体脂肪移植技术改善了一名患有残端指溃疡的硬皮病患者的伤口愈合情况，此前所有其他治疗方法均告失败。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f86/7889081/a68bc2d2f8f4/ICRP_A_1881521_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f86/7889081/835594daded9/ICRP_A_1881521_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f86/7889081/a68bc2d2f8f4/ICRP_A_1881521_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f86/7889081/835594daded9/ICRP_A_1881521_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f86/7889081/a68bc2d2f8f4/ICRP_A_1881521_F0002_C.jpg

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本文引用的文献

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Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels.脂肪来源、血液来源和纤维素材料在皮肤伤口再生中的临床转化潜力：细胞、外泌体和水凝胶。
Biomolecules. 2020 Sep 27;10(10):1373. doi: 10.3390/biom10101373.
2
Autologous Fat Grafting for the Oral and Digital Complications of Systemic Sclerosis: Results of a Prospective Study.自体脂肪移植治疗系统性硬化症的口腔和数字并发症：一项前瞻性研究的结果。
Aesthetic Plast Surg. 2020 Oct;44(5):1820-1832. doi: 10.1007/s00266-020-01848-2. Epub 2020 Jul 6.
3
Fat Grafting for the Treatment of Scleroderma.
脂肪移植通过脂肪细胞的去分化和再分化诱导真皮脂肪再生并逆转皮肤纤维化。
Stem Cell Res Ther. 2022 Oct 9;13(1):499. doi: 10.1186/s13287-022-03127-0.
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Systemic sclerosis cutaneous expression: Management of skin fibrosis and digital ulcers.系统性硬化症的皮肤表现：皮肤纤维化和指端溃疡的管理
Ann Med Surg (Lond). 2021 Nov 2;71:102984. doi: 10.1016/j.amsu.2021.102984. eCollection 2021 Nov.
脂肪移植治疗硬皮病。
Plast Reconstr Surg. 2019 Dec;144(6):1498-1507. doi: 10.1097/PRS.0000000000006291.
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Role of Fat Graft Alone versus Enriched Fat Graft with Stromal Vascular Filtrate in Painful Amputation Stump.单纯脂肪移植与富含基质血管成分的脂肪移植在截肢残端疼痛中的作用
Indian J Orthop. 2019 May-Jun;53(3):452-458. doi: 10.4103/ortho.IJOrtho_385_18.
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Could autologous adipose-derived stromal vascular fraction turn out an unwanted source of profibrotic myofibroblasts in systemic sclerosis?自体脂肪来源的基质血管成分会成为系统性硬化症中促纤维化肌成纤维细胞的意外来源吗？
Ann Rheum Dis. 2020 May;79(5):e55. doi: 10.1136/annrheumdis-2019-215288. Epub 2019 Mar 13.
6
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Arthritis Res Ther. 2019 Jan 7;21(1):7. doi: 10.1186/s13075-018-1792-8.
7
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Off-label use of adipose-derived stem cells.脂肪来源干细胞的非标签使用。
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