Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, China.
Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1724-1731. doi: 10.26355/eurrev_202102_24882.
The outbreak of COVID-19 seriously affected people's life and safety, and it has not been effectively controlled all over the world at present. The binding of S protein of SARS-COV-2 virus to ACE2 receptor requires the assistance of Transmembrane Serine Protease 2 (TMPRSS2), which can activate the S protein on the surface of virus and promote its binding to the ACE2 receptor. With the continuous accumulation of experience in the treatment of COVID-19 patients and the experimental studies of a large number of scientific researchers, it was found that COVID-19 patients had a higher mortality rate in patients with underlying diseases. Therefore, for COVID-19 patients with tumors, the mortality rate may be significantly higher than other people. Clinical studies had found that some patients were complicated with cytokine storm in clinical treatment, which was also the direct cause of death for some patients. The infiltration of immune cells and the release of a variety of cytokines were important factors causing cytokine storm. Therefore, for COVID-19 patients with tumors, it was of great clinical significance to explore the relationship between COVID-19 virus receptor ACE2, TMPRSS2 and immune cell infiltration, which can help clinicians to make some more appropriate treatment plans.
COVID-19 的爆发严重影响了人们的生活和安全，目前在全球范围内尚未得到有效控制。SARS-COV-2 病毒的 S 蛋白与 ACE2 受体的结合需要跨膜丝氨酸蛋白酶 2（TMPRSS2）的协助，它可以激活病毒表面的 S 蛋白，促进其与 ACE2 受体的结合。随着对 COVID-19 患者治疗经验的不断积累和大量科研人员的实验研究，发现患有基础疾病的 COVID-19 患者死亡率更高。因此，对于患有肿瘤的 COVID-19 患者，死亡率可能明显高于其他人。临床研究发现，一些患者在临床治疗中并发细胞因子风暴，这也是一些患者死亡的直接原因。免疫细胞的浸润和各种细胞因子的释放是导致细胞因子风暴的重要因素。因此，对于患有肿瘤的 COVID-19 患者，探索 COVID-19 病毒受体 ACE2、TMPRSS2 与免疫细胞浸润的关系具有重要的临床意义，这有助于临床医生制定更合适的治疗方案。
