Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
The Jackson Heart Study, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Mol Nutr Food Res. 2021 Apr;65(8):e2000796. doi: 10.1002/mnfr.202000796. Epub 2021 Mar 11.
New biomarkers are needed that are representative of dietary intake.
We assess metabolites associated with Southern dietary patterns in 1401 Jackson Heart Study participants. Three dietary patterns are empirically derived using principal component analysis: meat and fast food, fish and vegetables, and starchy foods. We randomly select two subsets of the study population: two-third sample for discovery (n = 934) and one-third sample for replication (n = 467). Among the 327 metabolites analyzed, 14 are significantly associated with the meat and fast food dietary pattern, four are significantly associated with the fish and vegetables dietary pattern, and none are associated with the starchy foods dietary pattern in the discovery sample. In the replication sample, nine remain associated with the meat and fast food dietary pattern [indole-3-propanoic acid, C24:0 lysophosphatidylcholine (LPC), N-methyl proline, proline betaine, C34:2 phosphatidylethanolamine (PE) plasmalogen, C36:5 PE plasmalogen, C38:5 PE plasmalogen, cotinine, hydroxyproline] and three remain associated with the fish and vegetables dietary pattern [1,7-dimethyluric acid, C22:6 lysophosphatidylethanolamine, docosahexaenoic acid (DHA)].
Twelve metabolites are discovered and replicated in association with dietary patterns detected in a Southern U.S. African-American population, which could be useful as biomarkers of Southern dietary patterns.
需要有代表性的饮食摄入的新型生物标志物。
我们评估了 1401 名杰克逊心脏研究参与者中与南方饮食模式相关的代谢物。使用主成分分析从经验上得出三种饮食模式：肉类和快餐、鱼类和蔬菜以及淀粉类食物。我们随机选择研究人群的两个子集：用于发现的三分之二样本（n=934）和用于复制的三分之一样本（n=467）。在分析的 327 种代谢物中，有 14 种与肉类和快餐饮食模式显著相关，有 4 种与鱼类和蔬菜饮食模式显著相关，而在发现样本中没有与淀粉类食物饮食模式相关的代谢物。在复制样本中，有 9 种仍与肉类和快餐饮食模式相关[吲哚-3-丙酸、C24：0 溶血磷脂酰胆碱（LPC）、N-甲基脯氨酸、脯氨酸甜菜碱、C34：2 磷脂酰乙醇胺（PE）醚、C36：5 PE 醚、C38：5 PE 醚、可替宁、羟脯氨酸]，有 3 种仍与鱼类和蔬菜饮食模式相关[1,7-二甲基尿酸、二十二碳六烯酸（DHA）、二十二碳六烯酸]。
在一项美国南部非裔美国人的研究中发现并复制了 12 种与饮食模式相关的代谢物，这些代谢物可能作为南方饮食模式的生物标志物。
