SUNY Upstate Medical University, Syracuse, NY, USA.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:2324709621997282. doi: 10.1177/2324709621997282.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a constellation of symptoms that manifest as a result of certain medications. Several antipsychotics, antibiotics, and sulfa-containing drugs are known to be implicated in the etiology of DRESS syndrome. The clinical presentation of this disorder consists of a diffuse rash, lymphadenopathy, and systemic organ damage. Our patient presented with symptoms consistent with DRESS syndrome after being started on leflunomide, which is not commonly associated with DRESS. The diagnostic workup comprised of monitoring inflammatory markers on laboratory work, an excisional lymph node biopsy (to rule out malignancy), and a skin biopsy (to assess the etiology of the rash). Our patient received systemic steroids, dose-adjusted based on expert opinion. Further research is required to explore the association between leflunomide and DRESS and address guidelines for the management of DRESS.
药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征是由某些药物引起的一系列症状。几种抗精神病药、抗生素和含磺胺类药物已知与 DRESS 综合征的病因有关。该疾病的临床表现包括弥漫性皮疹、淋巴结病和全身器官损伤。我们的患者在开始使用来氟米特后出现符合 DRESS 综合征的症状，而后者通常与 DRESS 无关。诊断工作包括监测实验室检查中的炎症标志物、切除性淋巴结活检（排除恶性肿瘤）和皮肤活检（评估皮疹的病因）。我们的患者接受了基于专家意见调整剂量的全身类固醇治疗。需要进一步研究来探讨来氟米特与 DRESS 之间的关联，并制定 DRESS 管理指南。
