Department of Neurological Surgery, Weill Cornell Medicine, New York, NY, USA.
Weill Cornell Medical College, New York, NY, USA.
Curr Oncol Rep. 2021 Feb 25;23(3):35. doi: 10.1007/s11912-020-01005-7.
This review summarizes the modern approach to surgical management of malignant brain tumors, highlighting new technology and multimodal treatment paradigms.
Outcomes in patients with glioblastoma are strongly correlated with extent of initial surgical resection. Intraoperative MRI, 5-ALA, and neuronavigation are surgical tools that can help achieve a maximal safe resection. Stereotactic radiosurgery and brachytherapy can be used to enhance local control for brain metastases in conjunction with surgery, while combinatorial approaches are increasingly employed in patients with multiple metastases. Advances in surgical techniques allow for minimally invasive approaches, including the use of tubular retractors, endoscopes, and laser interstitial thermal therapy. Primary and metastatic brain tumors require a multimodal, multidisciplinary approach to treatment. Surgical resection can be paired with radiation for metastases to maximize tumor control, expanding systemic options. Technological innovations have improved the safety of surgical resection, while expanding the surgical options and indications for treatment.
本文总结了恶性脑肿瘤的现代外科治疗方法,重点介绍了新技术和多模式治疗方案。
胶质母细胞瘤患者的预后与初始手术切除范围密切相关。术中磁共振成像、5-ALA 和神经导航是有助于实现最大安全切除的手术工具。立体定向放射外科和近距离放疗可与手术联合用于增强脑转移瘤的局部控制,而组合方法在多发转移瘤患者中越来越多地应用。手术技术的进步使得微创方法得以实现,包括使用管状牵开器、内窥镜和激光间质热疗。原发性和转移性脑肿瘤的治疗需要采用多模式、多学科的方法。对于转移瘤,手术切除可与放疗联合,以最大限度地控制肿瘤,扩大全身治疗选择。技术创新提高了手术切除的安全性,同时扩大了手术选择和治疗适应证。