Department of Microbiology and Immunology, Medical College of Virginia and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA.
Hepatology. 2021 Sep;74(3):1652-1659. doi: 10.1002/hep.31765. Epub 2021 Aug 30.
The rapid advance in deep sequencing technologies has identified numerous long non-coding RNAs (lncRNA) and their biological functions are increasingly being recognized as important regulators of gene expression and cell signaling pathways. H19 is the first lncRNA identified and characterized as the first imprinted gene in the pre-genomic era. During the last three decades, H19 has been extensively investigated as a multitasking lncRNA. H19 plays a crucial role in regulating many biological functions and is intimately involved in the pathogenesis of various human diseases. Here, we highlight the recent findings related to H19 in liver diseases. The unique features of H19 biogenesis and regulation make it an attractive diagnostic and prognostic biomarker and potential therapeutic target for certain liver diseases.
: The roles of H19 in liver disease remains obscure. The rapid advance in new technologies offers promise for the understanding of the mechanisms of lncRNA H19 in physiological and pathological processes of liver diseases and for the development novel therapeutics.
深度测序技术的快速发展已经鉴定出许多长非编码 RNA（lncRNA），其生物学功能越来越被认为是基因表达和细胞信号通路的重要调节剂。H19 是第一个被鉴定并被特征化为前基因组时代第一个印记基因的 lncRNA。在过去的三十年中，H19 作为一种多功能 lncRNA 得到了广泛的研究。H19 在调节许多生物功能中起着至关重要的作用，并且与各种人类疾病的发病机制密切相关。在这里，我们强调了与肝脏疾病相关的 H19 的最新发现。H19 生物发生和调节的独特特征使其成为某些肝脏疾病有吸引力的诊断和预后生物标志物和潜在治疗靶点。
H19 在肝脏疾病中的作用尚不清楚。新技术的快速发展有望理解 lncRNA H19 在肝脏疾病生理和病理过程中的作用，并为开发新的治疗方法提供了可能。
