From the Departments of Otorhinolaryngology and Head and Neck Surgery.
Nuclear Medicine.
Clin Nucl Med. 2021 Jul 1;46(7):e389-e390. doi: 10.1097/RLU.0000000000003540.
Somatostatin cell surface receptors are expressed in many different benign and malignant tumors and are often exploited for imaging and therapy of neuroendocrine tumors. A 17-year-old adolescent boy with clinicoradiologically diagnosed JNA (juvenile nasopharyngeal angiofibroma) also underwent 68Ga-DOTANOC PET to explore somatostatin cell surface receptors' expression and its theranostic potential. Fusion PET/MRI, a novel imaging technology, exactly depicted the anatomical extensions of the tumor with avid DOTANOC uptake. This software-based fusion technique is advantageous for easy early recurrence identification, better delineation from postoperative scar tissue, for planning the exact target volumes for stereotactic radiotherapy therapy of inoperable/residual/recurrent JNAs in the future.
生长抑素细胞表面受体在许多不同的良性和恶性肿瘤中表达，常用于神经内分泌肿瘤的成像和治疗。一位 17 岁的青少年男性，经临床和影像学诊断为 JNA（青少年鼻咽血管纤维瘤），还接受了 68Ga-DOTANOC PET 检查，以探索生长抑素细胞表面受体的表达及其治疗潜力。融合 PET/MRI 是一种新的成像技术，能准确显示肿瘤的解剖学延伸，并摄取大量的 DOTANOC。这种基于软件的融合技术有利于早期识别容易复发的部位，与术后疤痕组织更好地区分，以便为未来无法手术/残留/复发的 JNA 患者进行立体定向放疗治疗的精确靶区勾画。
