From the Departments of Otorhinolaryngology & Head and Neck Surgery.
Nuclear Medicine.
Clin Nucl Med. 2020 Apr;45(4):308-309. doi: 10.1097/RLU.0000000000002951.
Prostate-specific membrane antigen (PSMA) is expressed in the endothelial cells of tumor-associated neovasculature of various nonprostatic benign and malignant neoplasms including juvenile nasopharyngeal angiofibroma (JNA). Positive uptake on PET/CT imaging with Ga-labeled PSMA is noted in a patient with residual disease after initial surgery without any abnormal uptake in postoperative fibrosis, in contrast to contrast-enhanced MRI, which was confirmed by biopsy. Ga-PSMA PET/CT may be a useful tool clinically for identifying early biochemical recurrences and in specifically differentiating recurrences from surgical site reparative tissue.
前列腺特异性膜抗原（PSMA）表达于多种非前列腺良恶性肿瘤相关新生血管内皮细胞中，包括青少年鼻咽血管纤维瘤（JNA）。与增强 MRI 相比，Ga 标记的 PSMA 行 PET/CT 成像时，在初始手术后有残留疾病的患者中可出现阳性摄取，而术后纤维化中无异常摄取，后者得到了活检的证实。Ga-PSMA PET/CT 可能是临床上用于识别早期生化复发并特异性区分复发与手术部位修复组织的有用工具。
