From the Departments of Otorhinolaryngology and Head and Neck Surgery, and.
Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Clin Nucl Med. 2019 Feb;44(2):e118-e119. doi: 10.1097/RLU.0000000000002387.
The prostate-specific membrane antigen (PSMA) is highly expressed in prostatic cancer. However, PSMA expression is also noted in various benign and malignant nonprostatic neoplasms in the endothelial cells of tumor-associated neovasculature. We performed Ga-PSMA PET/CT in a 14-year-old boy with juvenile nasal angiofibroma (JNA) to explore its theranostic potential. The scan revealed high uptake in the lesion. Performance of PSMA PET/CT in JNA opens up new frontiers with respect to radiological staging, early recurrence identification, and perhaps even radioligand therapy of residual/recurrent JNAs in the future.
前列腺特异性膜抗原（PSMA）在前列腺癌中高度表达。然而，PSMA 的表达也见于肿瘤相关新生血管内皮细胞中的各种良性和恶性非前列腺肿瘤。我们对一名 14 岁的少年鼻血管纤维瘤（JNA）患者进行了 Ga-PSMA PET/CT 检查，以探索其治疗潜力。扫描显示病变部位摄取量高。PSMA PET/CT 在 JNA 中的应用为放射学分期、早期复发识别，甚至未来残留/复发性 JNA 的放射性配体治疗开辟了新的领域。
