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[肾上腺素对电离辐射后大鼠外周血淋巴细胞琥珀酸脱氢酶活性的影响]

[Effect of adrenaline on the succinate dehydrogenase activity of peripheral blood lymphocytes of rats following exposure to ionizing radiation].

作者信息

Koroleva L V, Vasin M V

出版信息

Radiobiologiia. 1988 Mar-Apr;28(2):228-30.

PMID:3363101
Abstract

In experiments with albino mongrel female rats, the influence of adrenaline on succinate dehydrogenase (SDG) activity in the peripheral blood lymphocytes of irradiated and intact animals has been investigated. Two minutes after the intraperitoneal administration of adrenaline (1 mg/kg) to intact rats SDG activity sharply rises and 3-4 min it drastically falls. In 6 to 8 min the second peak in the enzyme activity is registered. Twenty minutes after irradiation of rats in the cranio-caudal direction with a dose of 75 Gy delivered to head, the reaction to adrenaline, manifested by the rise in SDG activity, is absent.

摘要

在对白化杂种雌性大鼠进行的实验中,研究了肾上腺素对受辐照和未受辐照动物外周血淋巴细胞中琥珀酸脱氢酶(SDG)活性的影响。给未受辐照的大鼠腹腔注射肾上腺素(1毫克/千克)两分钟后,SDG活性急剧上升,3 - 4分钟后急剧下降。在6至8分钟时记录到酶活性的第二个峰值。用75戈瑞的剂量对头进行颅尾方向辐照大鼠20分钟后,对肾上腺素的反应(表现为SDG活性升高)消失。

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