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[肾上腺素对功能改变(淋巴细胞性白血病)的小鼠淋巴细胞中琥珀酸脱氢酶活性的影响]

[The effect of adrenaline on the succinate dehydrogenase activity in functionally changed (lymphoid leukosis) lymphocytes in mice].

作者信息

Davydov B I, Gaĭdamakin A N, L'vova T S, Romaniuk N N

出版信息

Kosm Biol Aviakosm Med. 1991 Jan-Feb;25(1):46-9.

PMID:2046301
Abstract

The activity of succinate dehydrogenase (SDH) in lymphocytes of peripheral blood of AKR mice was measured in response to intraperitoneal injection of epinephrine hydrochloride at a dose of 1 mg/kg. SDH reactions to epinephrine were of two types: increase or decrease of activity. The type of reaction depended on the initial enzyme level. The decrease of epinephrine activation of SDH in lymphocytes was found to be correlated with the age of animals and hematological manifestations of hemoblastosis they developed. The percentage of cells with a high SDH activity in hemoblastotic animals was correlated with the count of prolymphocytes and blast cells in peripheral blood.

摘要

以1mg/kg的剂量腹腔注射盐酸肾上腺素后,测定了AKR小鼠外周血淋巴细胞中琥珀酸脱氢酶(SDH)的活性。SDH对肾上腺素的反应有两种类型:活性增加或降低。反应类型取决于初始酶水平。发现淋巴细胞中SDH的肾上腺素激活降低与动物年龄及其所患成血病的血液学表现相关。成血病动物中具有高SDH活性的细胞百分比与外周血中前淋巴细胞和原始细胞的计数相关。

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