Department of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Kaneryo Sea Vegetable Corporation, 1544 Sasawara-machi, Uto-shi, Kumamoto 869-0402, Japan.
Fitoterapia. 2021 Jun;151:104861. doi: 10.1016/j.fitote.2021.104861. Epub 2021 Feb 22.
Propolis is a chemically complex resinous product collected from various plant sources by honeybees that has been used historically a traditional folk medicine in many parts of the world. The main constituents of propolis are beeswax and plant resins. We recently obtained Senegalese propolis, which, to our knowledge, has not been previously reported. The purpose of this study was to analyze the composition of Senegalese propolis and evaluate its anti-inflammatory activity. Ten known phenolic compounds with phenanthrene or stilbene skeletons were isolated. Nitric oxide (NO) production assay revealed that Senegalese propolis suppresses lipopolysaccharide (LPS)-stimulated production of NO in J774.1 cells in a dose-dependent manner. The anti-inflammatory potency of Senegalese propolis was higher than that of other previously reported propolis. Furthermore, the eight compounds isolated from Senegalese propolis showed high anti-inflammatory activity by inhibiting the LPS-induced expression of inducible NO synthase (iNOS). These results suggest that Senegalese propolis and its components have potential applications as anti-inflammatory agents.
蜂胶是一种由蜜蜂从各种植物源中采集的化学成分复杂的树脂状产物，在世界许多地方，它一直被用作传统的民间药物。蜂胶的主要成分是蜂蜡和植物树脂。我们最近获得了塞内加尔蜂胶，据我们所知，这种蜂胶以前尚未有报道。本研究的目的是分析塞内加尔蜂胶的组成并评估其抗炎活性。分离得到了 10 种具有菲或芪骨架的已知酚类化合物。一氧化氮（NO）产生测定表明，塞内加尔蜂胶以剂量依赖性方式抑制脂多糖（LPS）刺激的 J774.1 细胞中 NO 的产生。塞内加尔蜂胶的抗炎效力高于以前报道的其他蜂胶。此外，从塞内加尔蜂胶中分离得到的 8 种化合物通过抑制 LPS 诱导的诱导型一氧化氮合酶（iNOS）的表达显示出很强的抗炎活性。这些结果表明，塞内加尔蜂胶及其成分具有作为抗炎剂的应用潜力。
