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壳聚糖/磷酸钙复合材料的制备及应用研究进展。

Recent progress in preparation and applications of chitosan/calcium phosphate composite materials.

机构信息

Cellulose and Paper Department, National Research Centre, 33 El-Bohouth st., Dokki, P.O. 12622, Giza, Egypt.

出版信息

Int J Biol Macromol. 2021 May 1;178:240-252. doi: 10.1016/j.ijbiomac.2021.02.143. Epub 2021 Feb 22.

Abstract

Studying the development of unique materials from sustainable and renewable resources has gained increasing concern due to the depletion of fossil resources. Chitosan and its derivatives have been considered as versatile candidates for preparing attractive materials. The fabrication of chitosan/calcium phosphate composite compounds has received much attention for the development of numerous promising products in different fields. In this short review, recent preparation strategies for chitosan/calcium phosphate composites such as freeze casting, vacuum-assisted filtration, and biomimetic mineralization were discussed. The review presented their advances for diverse applications such as bone tissue engineering implants, drug delivery, wound healing, dental caries, as well adsorption of organic and heavy metals from polluted water. The challenges and future perspectives for the application of chitosan/calcium phosphate materials in biomedical and environmental applications were also involved in this review article.

摘要

由于化石资源的枯竭,研究从可持续和可再生资源中开发独特材料的方法受到了越来越多的关注。壳聚糖及其衍生物已被认为是制备有吸引力材料的多功能候选材料。壳聚糖/磷酸钙复合化合物的制备受到了广泛关注,因为它可以开发出许多在不同领域有应用前景的产品。在这篇简短的综述中,讨论了壳聚糖/磷酸钙复合材料的最新制备策略,如冷冻铸造、真空辅助过滤和仿生矿化。综述了它们在骨组织工程植入物、药物输送、伤口愈合、龋齿以及从受污染的水中吸附有机和重金属等多个领域的应用进展。本文还涉及了壳聚糖/磷酸钙材料在生物医学和环境应用中的应用的挑战和未来展望。

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