Department of Pediatrics, School of Medicine, and Doernbecher Tom Sargent Safety Center, Doernbecher Children's Hospital, Oregon Health and Science University (BD Hoffman, TA Gilbert, K Chan, B Ennis, and A Gallardo), Portland, Ore.
Oregon Health and Science University-Portland State University (OHSU-PSU) School of Public Health, Oregon Health and Science University (KF Carlson), Portland, Ore.
Acad Pediatr. 2021 Nov-Dec;21(8):1355-1362. doi: 10.1016/j.acap.2021.02.012. Epub 2021 Feb 22.
The American Academy of Pediatrics recommends pre-discharge Car Seat Tolerance Screening (CSTS) for all neonates born <37 weeks estimated gestational age (EGA), or otherwise at risk for cardiorespiratory compromise. Screening is burdensome and there remains tremendous variation in testing criteria and methodology.
DESIGN/METHODS: We conducted a retrospective chart review of 1,072 infants who underwent CSTS between 11/2013 and 7/2016 at a single academic health center. CSTS outcomes (failure and, separately, significant cardiorespiratory instability (CRI)), including those not meeting failure thresholds) were analyzed for all infants screened, and for preterm infants by screening location (Neonatal Intensive Care Unit (NICU) and Mother/Baby Unit (MBU)). Logistic regression was used to estimate associations between infant characteristics and CSTS outcomes.
Overall incidence of CSTS failure was 9.2%. Among all infants, hemodynamically significant congenital heart disease, apnea, chronic lung disease, and being small for EGA were associated with failure. Additionally, those born ≤28 weeks EGA had 2.4 times greater likelihood of failure than those 34-36 weeks EGA. Among preterm infants in the NICU and MBU, those of earlier EGA were also more likely to fail. Almost half (47.5%) of all preterm infants demonstrated CRI during CSTS.
We found high CSTS failure rates, and identified key infant characteristics that were associated with increased likelihood of failure. Significant CRI events were remarkably common. Larger, prospective studies are needed to elucidate risk factors for instability and failure and define practical criteria for CSTS recommendations.
美国儿科学会建议对所有胎龄<37 周(估计胎龄)或存在心肺功能受损风险的新生儿进行出院前汽车座椅耐受性筛查(CSTS)。筛查工作繁重,且测试标准和方法存在巨大差异。
方法/设计:我们对 2013 年 11 月至 2016 年 7 月在一家学术医疗中心接受 CSTS 的 1072 名婴儿进行了回顾性图表审查。对所有接受筛查的婴儿以及按筛查地点(新生儿重症监护病房(NICU)和母婴病房(MBU))分类的早产儿进行 CSTS 结果(失败和单独的心肺功能显著不稳定(CRI))分析,包括未达到失败阈值的婴儿。使用逻辑回归估计婴儿特征与 CSTS 结果之间的关联。
CSTS 失败的总体发生率为 9.2%。在所有婴儿中,与 CSTS 失败相关的特征包括存在严重先天性心脏病、呼吸暂停、慢性肺病和胎龄小。此外,胎龄≤28 周的婴儿比胎龄 34-36 周的婴儿失败的可能性高 2.4 倍。在 NICU 和 MBU 中的早产儿中,胎龄较早的婴儿也更有可能失败。几乎一半(47.5%)的早产儿在 CSTS 期间出现 CRI。
我们发现 CSTS 失败率较高,并确定了与失败可能性增加相关的关键婴儿特征。显著的 CRI 事件非常常见。需要更大规模的前瞻性研究来阐明不稳定和失败的危险因素,并为 CSTS 建议定义实用的标准。