Frisancho A R
Center for Human Growth and Development, University of Michigan, Ann Arbor 48109.
Respir Physiol. 1988 Apr;72(1):13-8. doi: 10.1016/0034-5687(88)90075-8.
Mean hemoglobin concentration of 3511 adult males derived from 19 studies of Andean male permanent residents and 10 studies of Himalayan male permanent residents were compared with reference to partial pressure of inspired oxygen. The regression equation (weighted for sample size) of PIO2 and hemoglobin concentration of the Andean miners is significantly (P less than 0.01) greater than that of the Andean and Himalayan non-miners. However, the relationship of PIO2 and Hb is similar in the non-mining Andean and Himalayan samples. These findings suggest that the observed differences in hemoglobin concentration between Andean and Himalayan samples are due, in part, to the inclusion of miners in the Andean samples. The higher barometric pressure associated with the north latitude location of the Himalayans may also contribute to decrease the hypoxic stress in the Himalayas. The present data suggest that Andeans and Himalayans have a similar hemopoietic response to hypoxic stress.
对来自19项关于安第斯男性永久居民的研究和10项关于喜马拉雅男性永久居民的研究中的3511名成年男性的平均血红蛋白浓度，参照吸入氧分压进行了比较。安第斯矿工的吸入氧分压（PIO2）与血红蛋白浓度的回归方程（按样本量加权）显著（P小于0.01）高于安第斯和喜马拉雅非矿工的回归方程。然而，在非采矿的安第斯和喜马拉雅样本中，PIO2与血红蛋白（Hb）的关系相似。这些发现表明，安第斯和喜马拉雅样本中观察到的血红蛋白浓度差异部分归因于安第斯样本中纳入了矿工。与喜马拉雅山脉北纬位置相关的较高气压也可能有助于降低喜马拉雅地区的缺氧应激。目前的数据表明，安第斯人和喜马拉雅人对缺氧应激具有相似的造血反应。
