Department of Otolaryngology, Columbus Clinic Center, Milan, Italy.
J Laryngol Otol. 2021 Mar;135(3):224-228. doi: 10.1017/S0022215121000670. Epub 2021 Feb 26.
Severe acute respiratory syndrome coronavirus-2 is a formidable virus, responsible for coronavirus disease 2019 and endowed with marked neurotropism. The damage it causes to the nervous system is manifold. The main neurological manifestation is anosmia. Olfactory damage is often transient, but there are no data reflecting an observational period of several months.
This study evaluated the trend of anosmia in patients affected by coronavirus disease 2019 in the eight months following diagnosis.
Fifty-five subjects who presented with symptoms suggestive of coronavirus disease 2019 and who developed anosmia, between the end of February and the beginning of March 2020, were investigated. The patients were interviewed after eight months to determine functional recovery and assess the degree of recovery.
Ninety-one per cent of the population reported olfactory recovery and, of these, 53 per cent had total recovery after eight months. Females and younger age groups seem slightly advantaged in functional recovery. The elderly population appears to have excellent prospects for full functional recovery.
Anosmia represents a frequent neurological manifestation during coronavirus disease 2019. Fortunately, it is transient in most cases, and only a small percentage of patients affected by it report long-term functional deficits.
严重急性呼吸综合征冠状病毒 2 是一种强大的病毒，它引发了 2019 年冠状病毒病，并具有明显的嗜神经性。它对神经系统造成的损害是多方面的。主要的神经系统表现为嗅觉丧失。嗅觉损伤通常是短暂的，但没有反映观察期为几个月的数据。
本研究评估了诊断后 8 个月内感染 2019 年冠状病毒病患者的嗅觉丧失趋势。
对 2020 年 2 月底至 3 月初出现 2019 年冠状病毒病症状并出现嗅觉丧失的 55 名患者进行了调查。在 8 个月后对患者进行了访谈，以确定功能恢复情况并评估恢复程度。
91%的患者报告嗅觉恢复，其中 53%的患者在 8 个月后完全恢复嗅觉。女性和年龄较小的群体在功能恢复方面似乎略有优势。老年人群似乎有很好的完全功能恢复前景。
嗅觉丧失是 2019 年冠状病毒病期间常见的神经系统表现。幸运的是，在大多数情况下它是短暂的，只有一小部分受其影响的患者报告存在长期的功能缺陷。
