Department of Otolaryngology - Head and Neck Surgery, Azienda Ospedaliero Universitaria (AOU) Policlinico and University of Modena and Reggio Emilia, Modena, Italy.
Department of Otolaryngology - Head and Neck Surgery, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico Sant'Orsola-Malpighi, Bologna, Italy.
J Laryngol Otol. 2022 Mar;136(3):237-242. doi: 10.1017/S0022215121004047. Epub 2021 Dec 13.
This study aimed to assess the olfactory recovery rates and patterns in a cohort of coronavirus disease 2019 positive patients, and to investigate the clinical predictors of poor long-term olfactory restoration.
An observational retrospective study was conducted on 146 patients between September 2020 and January 2021 at a tertiary referral hospital. Coronavirus disease 2019 positive patients with olfactory dysfunction were sent a modified version of the COVID-19 Anosmia Reporting Tool for Clinicians via e-mail.
The difference in median recovery time between complete recovery and incomplete or no recovery was statistically significant. On multivariate analysis, the only significant factor associated with incomplete or no recovery was anosmia duration.
After a mean time of 5.6 months from severe acute respiratory syndrome coronavirus-2 infection, persistent olfactory disorders were self-reported in 36.7 per cent of patients. Complete recovery was more likely to occur within 15 days. Given the high prevalence of coronavirus disease 2019, a large number of patients are expected to suffer from long-term olfactory morbidity.
本研究旨在评估一组新型冠状病毒肺炎阳性患者的嗅觉恢复率和模式，并探讨长期嗅觉恢复不良的临床预测因素。
对 2020 年 9 月至 2021 年 1 月期间在一家三级转诊医院的 146 名患者进行了一项观察性回顾性研究。通过电子邮件向嗅觉功能障碍的新型冠状病毒肺炎阳性患者发送了经改良的临床医生使用的 COVID-19 嗅觉丧失报告工具。
完全恢复与不完全或无恢复之间的中位恢复时间差异具有统计学意义。多变量分析显示，与不完全或无恢复相关的唯一显著因素是嗅觉丧失持续时间。
在严重急性呼吸综合征冠状病毒-2 感染后平均 5.6 个月，36.7%的患者自我报告存在持续性嗅觉障碍。完全恢复更有可能在 15 天内发生。鉴于新型冠状病毒病的高患病率，预计大量患者将长期出现嗅觉障碍。
