Department of Biostatistics, Epidemiology, and Occupational Health, McGill University, Montreal, QC, Canada.
Division of Newborn Medicine, Boston Children's Hospital, Boston 02115, MA, United States.
Cereb Cortex. 2024 Jun 4;34(6). doi: 10.1093/cercor/bhae224.
Congenital heart disease affects 1% of infants and is associated with impaired neurodevelopment. Right- or left-sided sulcal features correlate with executive function among people with Tetralogy of Fallot or single ventricle congenital heart disease. Studies of multiple congenital heart disease types are needed to understand regional differences. Further, sulcal pattern has not been studied in people with d-transposition of the great arteries. Therefore, we assessed the relationship between sulcal pattern and executive function, general memory, and processing speed in a meta-regression of 247 participants with three congenital heart disease types (114 single ventricle, 92 d-transposition of the great arteries, and 41 Tetralogy of Fallot) and 94 participants without congenital heart disease. Higher right hemisphere sulcal pattern similarity was associated with improved executive function (Pearson r = 0.19, false discovery rate-adjusted P = 0.005), general memory (r = 0.15, false discovery rate P = 0.02), and processing speed (r = 0.17, false discovery rate P = 0.01) scores. These positive associations remained significant in for the d-transposition of the great arteries and Tetralogy of Fallot cohorts only in multivariable linear regression (estimated change β = 0.7, false discovery rate P = 0.004; β = 4.1, false discovery rate P = 0.03; and β = 5.4, false discovery rate P = 0.003, respectively). Duration of deep hypothermic circulatory arrest was also associated with outcomes in the multivariate model and regression tree analysis. This suggests that sulcal pattern may provide an early biomarker for prediction of later neurocognitive challenges among people with congenital heart disease.
先天性心脏病影响 1%的婴儿，并与神经发育受损有关。法洛四联症或单心室先天性心脏病患者的右侧或左侧脑沟特征与执行功能相关。需要对多种先天性心脏病类型进行研究，以了解区域差异。此外，在大动脉转位的人中尚未研究脑沟模式。因此，我们评估了在三种先天性心脏病类型（114 例单心室、92 例大动脉转位和 41 例法洛四联症）和 94 例无先天性心脏病的 247 名参与者的荟萃回归中，脑沟模式与执行功能、一般记忆和处理速度之间的关系。较高的右半球脑沟模式相似性与执行功能（Pearson r=0.19，经错误发现率校正的 P=0.005）、一般记忆（r=0.15，错误发现率 P=0.02）和处理速度（r=0.17，错误发现率 P=0.01）评分的提高有关。这些正相关在大动脉转位和法洛四联症队列中仅在多变量线性回归中仍然显著（估计变化β=0.7，错误发现率 P=0.004；β=4.1，错误发现率 P=0.03；β=5.4，错误发现率 P=0.003）。深低温循环停搏的持续时间也与多变量模型和回归树分析中的结果相关。这表明脑沟模式可能为预测先天性心脏病患者后期神经认知挑战提供早期生物标志物。
