不同性别亮氨酸与糖尿病肾病的关系：中国 2 型糖尿病患者的横断面研究。
The Association Between Leucine and Diabetic Nephropathy in Different Gender: A Cross-Sectional Study in Chinese Patients With Type 2 Diabetes.
机构信息
Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Department of Blood Transfusion, Peking University People's Hospital, Beijing, China.
出版信息
Front Endocrinol (Lausanne). 2021 Feb 9;11:619422. doi: 10.3389/fendo.2020.619422. eCollection 2020.
OBJECTIVE
This study aimed to evaluate how leucine are associated with diabetic nephropathy (DN) in type 2 diabetes (T2D) patients and the gender difference of this association.
METHODS
We retrieved 1,031 consecutive patients with T2D who meet the inclusion and exclusion criteria from the same tertiary care center and extracted clinical information from electronic medical record. Plasma leucine was measured by liquid chromatography-mass spectrometer. Restricted cubic spline (RCS) was conducted to examine potential non-linear relationship between leucine and the risk of DN. Logistic regression was used to obtain odds ratio (OR) and confidence interval (CI). Additive interaction was used to estimate the interaction effect between leucine and gender for DN.
RESULTS
We found there was a negative correlation between leucine and the risk of DN. After stratifying all patients by gender, this relationship only remained significant in women (OR:0.57, CI:0.41-0.79).
CONCLUSIONS
In conclusion, T2D patients with high levels of leucine have a lower risk of developing DN in female.
目的
本研究旨在评估亮氨酸与 2 型糖尿病（T2D）患者糖尿病肾病（DN）的关系，以及这种关系的性别差异。
方法
我们从同一三级保健中心检索了 1031 例符合纳入和排除标准的 T2D 连续患者，并从电子病历中提取临床信息。采用液相色谱-质谱法测定血浆亮氨酸水平。采用限制性立方样条（RCS）检查亮氨酸与 DN 风险之间的潜在非线性关系。采用 logistic 回归获得比值比（OR）和置信区间（CI）。采用加法交互作用估计亮氨酸和性别对 DN 的交互作用效应。
结果
我们发现亮氨酸与 DN 风险之间呈负相关。对所有患者进行性别分层后，这种关系仅在女性中仍具有统计学意义（OR：0.57，CI：0.41-0.79）。
结论
总之，T2D 患者中亮氨酸水平较高的女性发生 DN 的风险较低。
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