Rossetti Tom, Jackvony Stephanie, Buck Jochen, Levin Lonny R
Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA.
Graduate Program in Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA.
Interface Focus. 2021 Apr 6;11(2):20200034. doi: 10.1098/rsfs.2020.0034. Epub 2021 Feb 12.
Soluble adenylyl cyclase (sAC; ADCY10) is a bicarbonate (HCO )-regulated enzyme responsible for the generation of cyclic adenosine monophosphate (cAMP). sAC is distributed throughout the cell and within organelles and, as such, plays a role in numerous cellular signalling pathways. Carbonic anhydrases (CAs) nearly instantaneously equilibrate HCO , protons and carbon dioxide (CO); because of the ubiquitous presence of CAs within cells, HCO -regulated sAC can respond to changes in any of these factors. Thus, sAC can function as a physiological HCO /CO/pH sensor. Here, we outline examples where we have shown that sAC responds to changes in HCO , CO or pH to regulate diverse physiological functions.
可溶性腺苷酸环化酶（sAC；ADCY10）是一种受碳酸氢盐（HCO₃⁻）调节的酶，负责生成环磷酸腺苷（cAMP）。sAC分布于整个细胞及细胞器内，因此在众多细胞信号通路中发挥作用。碳酸酐酶（CAs）能几乎瞬间使HCO₃⁻、质子和二氧化碳（CO₂）达到平衡；由于细胞内普遍存在CAs，受HCO₃⁻调节的sAC能够对这些因素中任何一个的变化做出反应。因此，sAC可作为一种生理性HCO₃⁻/CO₂/pH传感器。在此，我们概述了一些实例，表明sAC可对HCO₃⁻、CO₂或pH的变化做出反应，从而调节多种生理功能。
