通过碳酸氢盐调节的“可溶性”腺苷酸环化酶（sAC）进行pH传感。
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).
作者信息
Rahman Nawreen, Buck Jochen, Levin Lonny R
机构信息
Department of Pharmacology, Weill Cornell Medical College New York, NY, USA.
出版信息
Front Physiol. 2013 Nov 25;4:343. doi: 10.3389/fphys.2013.00343.
Abstract
Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3', 5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO(-) 3) ions. In living cells, HCO(-) 3 ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO(-) 3, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role.
摘要
可溶性腺苷酸环化酶（sAC）是第二信使环磷酸腺苷（cAMP）的来源。sAC直接受碳酸氢根（HCO₃⁻）离子调控。在活细胞中，由于碳酸酐酶无处不在，HCO₃⁻离子与二氧化碳（CO₂）及pH几乎瞬间达到平衡。许多生物过程受CO₂、HCO₃⁻和/或pH调控，其中有不少过程中，sAC已被证明可作为生理性CO₂/HCO₃⁻/pH传感器。在本综述中，我们详细阐述了sAC已知的pH传感功能，并讨论了sAC可能发挥作用的两条经过深入研究的pH依赖性途径。
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