Zhang Shiyu, Liu Yang
Department of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Tsinghua University, Beijing, China.
Front Chem. 2021 Feb 9;8:626243. doi: 10.3389/fchem.2020.626243. eCollection 2020.
High-performance nanomaterials have been seen as a new generation of electrochemiluminescence (ECL) probes or emitters for their finely tunable structure and concomitant remarkable properties, guaranteeing the prospective applications in the analysis and diagnosis devices with superior performances. The structure-activity relationships of ECL nanoprobes in nanoscale are presenting milestone in understanding of the ECL microscopic behaviors and mechanisms, and guide the exploitation of novel ECL probes. In this mini-review, we summarized the recent development of novel ECL probes based on the nanomaterials. The mechanism and relationships between their structure as well as the active sites and functionality were revealed. In addition, the design and regulation of the ECL nanoprobes were emphasized for the biosensing and imaging application. Finally, the potential prospect of the ECL nanoprobes, design, and their applications were discussed.
高性能纳米材料因其结构可精细调控以及随之而来的卓越性能，被视为新一代的电化学发光（ECL）探针或发光体，这保证了它们在具有卓越性能的分析和诊断设备中的潜在应用。纳米尺度下ECL纳米探针的构效关系是理解ECL微观行为和机制的里程碑，并指导新型ECL探针的开发。在本综述中，我们总结了基于纳米材料的新型ECL探针的最新进展。揭示了它们的结构、活性位点与功能之间的机制和关系。此外，还强调了ECL纳米探针在生物传感和成像应用中的设计与调控。最后，讨论了ECL纳米探针的潜在前景、设计及其应用。
