Gleason Karen K
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Front Bioeng Biotechnol. 2021 Jan 28;9:632753. doi: 10.3389/fbioe.2021.632753. eCollection 2021.
This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release.
本综述将聚焦于利用引发化学气相沉积（iCVD）生长的聚合物纳米层来控制药物和其他有机分子的释放。iCVD层能够贴合底层基材的几何形状，便于从具有高表面积的一维和二维纳米结构中释放。用于iCVD薄膜生长的反应器可针对特定的基材几何形状进行定制，并可扩大到较大的整体尺寸。气相沉积过程中不存在表面张力，即使对于厚度小于10 nm的iCVD层，也能合成无针孔的层。这种超薄层还能使药物快速穿过聚合物层。iCVD过程的温和条件避免了对被包封药物的损害。iCVD水凝胶能够响应pH值、温度或光，从而实现智能释放。可生物降解的iCVD层也已被证明可用于药物释放。
