心血管疾病患者中硒蛋白P的mRNA和蛋白水平表达与代谢综合征的关联：硒基因研究结果
Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study.
作者信息
Gharipour Mojgan, Sadeghi Masoumeh, Salehi Mansour, Behmanesh Mehrdad, Khosravi Elham, Dianatkhah Minoo, Haghjoo Javanmard Shaghayegh, Razavi Rouzbeh, Gharipour Amin
机构信息
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran.
出版信息
J Gene Med. 2017 Mar;19(3). doi: 10.1002/jgm.2945.
BACKGROUND
Selenoprotein P (SeP) is involved in transporting selenium from the liver to target tissues. Because SeP confers protection against disease by reducing chronic oxidative stress, the present study aimed to assess the level of SeP in the serum of patients with metabolic syndrome (MetS) with a history of cardiovascular disease (CVD).
METHODS
A cross-sectional study was conducted in 63 and 71 subjects with and without MetS in the presence of documented CVD. All demographic, anthropometric and cardiometabolic variables (lipids, blood glucose, blood pressure) were assessed. Lifestyle-related factors and personal history and familial CVD risk factors were recorded. The expression of SELP in mRNA and protein levels in the serum was measured, and MetS was determined using ATPIII criteria. Binary logistic regression analysis demonstrated MetS and SeP to be dependent and independent variables, respectively.
RESULTS
Mean of systolic and diastolic blood pressure, triglyceride, high-density lipoprotein-cholesterol, fasting blood sugar, body mass index and waist circumference were higher among subjects with MetS (p = 0.05). The mean of selenium was higher among subjects with MetS, whereas the mean of SeP was lower among subjects with MetS (p < 0.001). In the unadjusted model, the SeP had decreased odds for MetS [odds ratio (OR) = 0.995; 95% confidence interval (CI) = 0.989-1.00] (p < 0.04). Furthermore, the association between MetS and SeP levels remained marginally significant even after adjusting for potential confounders such as age, gender, family history, smoking status and nutrition. SeP and waist circumference show a significant relationship (OR =0.995; 95% CI = 0.990-1.00) (p < 0.033).
CONCLUSIONS
We have demonstrated a significant decrease in circulating SeP levels according to MetS status in patients with documented cardiovascular disease.
背景
硒蛋白P（SeP）参与将硒从肝脏转运至靶组织。由于SeP通过减轻慢性氧化应激赋予疾病防护作用，本研究旨在评估有心血管疾病（CVD）病史的代谢综合征（MetS）患者血清中SeP的水平。
方法
对63例有CVD记录且患有MetS的受试者以及71例有CVD记录但未患MetS的受试者进行了一项横断面研究。评估了所有人口统计学、人体测量学和心脏代谢变量（血脂、血糖、血压）。记录了与生活方式相关的因素、个人病史和家族性CVD危险因素。测定了血清中SELP在mRNA和蛋白质水平的表达，并使用ATPIII标准确定MetS。二元逻辑回归分析表明MetS和SeP分别为因变量和自变量。
结果
患有MetS的受试者的收缩压和舒张压、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、体重指数和腰围的平均值较高（p = 0.05）。患有MetS的受试者的硒平均值较高，而患有MetS的受试者的SeP平均值较低（p < 0.001）。在未调整模型中，SeP使患MetS的几率降低[比值比（OR）= 0.995；95%置信区间（CI）= 0.989 - 1.00]（p < 0.04）。此外，即使在调整了年龄、性别、家族史、吸烟状况和营养等潜在混杂因素后，MetS与SeP水平之间的关联仍微显显著。SeP与腰围呈显著关系（OR = 0.995；95% CI = 0.990 - 1.00）（p < 0.033）。
结论
我们已证实在有记录的心血管疾病患者中，循环SeP水平根据MetS状态显著降低。
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