Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, 151001, India.
National Institute of Biologicals, Sector 62, Noida-201309, India.
Clin Transl Oncol. 2021 Aug;23(8):1497-1510. doi: 10.1007/s12094-021-02552-6. Epub 2021 Feb 25.
Discoidin domain receptors, DDR1 and DDR2 are members of the receptor tyrosine kinase (RTK) family that serves as a non-integrin collagen receptor and were initially identified as critical regulators of embryonic development and cellular homeostasis. In recent years, numerous studies have focused on the role of these receptors in disease development, in particular, cancer where they have been reported to augment ECM remodeling, invasion, drug resistance to facilitate tumor progression and metastasis. Interestingly, accumulating evidence also suggests that DDRs promote apoptosis and suppress tumor progression in various human cancers due to which their functions in cancer remain ill-defined and presents a case of an interesting therapeutic target. The present review has discussed the role of DDRs in tumorigenesis and the metastasis.
Discoidin domain receptors, DDR1 and DDR2, 是受体酪氨酸激酶 (RTK) 家族的成员，它们作为非整联蛋白胶原受体，最初被确定为胚胎发育和细胞内稳态的关键调节剂。近年来，许多研究都集中在这些受体在疾病发展中的作用上，特别是在癌症中，它们被报道可以增强细胞外基质的重塑、侵袭、药物耐药性，从而促进肿瘤的进展和转移。有趣的是，越来越多的证据也表明，DDRs 会促进各种人类癌症中的细胞凋亡并抑制肿瘤进展，因此它们在癌症中的功能仍然不明确，并呈现出一个有趣的治疗靶点的情况。本综述讨论了 DDRs 在肿瘤发生和转移中的作用。
