Department of Rheumatology, "Reina Sofia University Hospital", Córdoba, and Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Spain.
Department of Rheumatology, "Reina Sofia University Hospital", Córdoba; Department of Medicine, University of Córdoba, and Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Spain.
Clin Exp Rheumatol. 2021 May-Jun;39 Suppl 130(3):82-88. doi: 10.55563/clinexprheumatol/zr61xv. Epub 2021 Feb 18.
To evaluate the association of the Assessment of Spondyloarthritis international Society Health Index (ASAS-HI) with disease activity and disease burden in patients with spondyloarthritis (SpA).
Observational, cross-sectional and single-centre study from the Córdoba AxSpA Task force, Registry and Outcomes (CASTRO). Scores related to disease activity (BASDAI and ASDAS), functionality (BASFI), structural damage, mobility, health and the presence of concomitant fibromyalgia (FM) were obtained from all patients. ASAS-HI score was considered the main outcome. Pearson's r statistic, Student's t test, and univariate and multivariate linear regressions were performed to assess the association between the ASAS-HI score and the studied covariates.
A total of 126 SpA patients were included. The mean ASAS-HI score was 4.6±3.9, showing a "strong" positive linear correlation (r>0.60) with the BASDAI and BASFI and a "moderate" positive linear correlation (r=0.40 to 0.60) with the global VAS and ASDAS. Patients with FM showed a significantly higher ASAS-HI score than patients without FM (9.5±3.2 vs. 3.7±3.4, respectively, p<0.01). Multiple linear regression showed that 57.4% of the ASAS-HI variability (R2=0.574) was explained by the presence of concomitant FM (β=2.23, 95% CI 0.73 to 3.80, p=0.004), higher scores on the BASDAI (β=0.62, 95% CI 0.25 to 0.97, p=0.001) and BASFI (β=0.57, 95% CI 0.26 to 0.88, p=0.001).
The impairment of health in patients with SpA was mainly associated with high disease activity, worsening functionality and with the presence of a possible concomitant FM. Therefore, in patients with high ASAS-HI scores we must evaluate the presence of concomitant FM.
评估强直性脊柱炎国际学会健康指数（ASAS-HI）与强直性脊柱炎（SpA）患者疾病活动度和疾病负担的相关性。
这是一项来自科尔多瓦 SpA 工作组、登记处和结果（CASTRO）的观察性、横断面和单中心研究。从所有患者中获得与疾病活动度（BASDAI 和 ASDAS）、功能（BASFI）、结构损伤、活动能力、健康状况以及合并纤维肌痛（FM）相关的评分。ASAS-HI 评分被视为主要结局。采用 Pearson r 统计量、学生 t 检验以及单变量和多变量线性回归分析来评估 ASAS-HI 评分与研究协变量之间的相关性。
共纳入 126 例 SpA 患者。平均 ASAS-HI 评分为 4.6±3.9，与 BASDAI 和 BASFI 呈“强”正线性相关（r＞0.60），与总体 VAS 和 ASDAS 呈“中度”正线性相关（r=0.40 至 0.60）。合并 FM 的患者 ASAS-HI 评分明显高于无 FM 的患者（分别为 9.5±3.2 和 3.7±3.4，p＜0.01）。多变量线性回归显示，FM 的存在（β=2.23，95%CI 为 0.73 至 3.80，p=0.004）可解释 ASAS-HI 变异的 57.4%（R2=0.574），BASDAI 评分较高（β=0.62，95%CI 为 0.25 至 0.97，p=0.001）和 BASFI 评分较高（β=0.57，95%CI 为 0.26 至 0.88，p=0.001）也与 ASAS-HI 评分有关。
SpA 患者的健康受损主要与疾病活动度高、功能恶化以及可能存在合并 FM 有关。因此，在 ASAS-HI 评分高的患者中，我们必须评估是否存在合并 FM。
