Tanno N, Koizumi M, Goto Y
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1988 Jan;154(1):11-20. doi: 10.1620/tjem.154.11.
We investigated the patients who underwent operation for cholelithiasis and the diabetic patients at our clinic in order to determine whether there was a significant relationship between the occurrence of cholesterol gallbladder stone and age, obesity, hyperlipidemia, diabetes mellitus and neuropathy. In 647 patients undergoing surgery, cholesterol gallstones were not highly associated with diabetes mellitus or hyperlipidemia, compared with calcium bilirubinate and black stones. Eighty-seven percent of the male operated patients and 88% of the female patients were over 40 years old of age. Of the female patients in whom gallstones were detected at surgery, 36% were obese. We found cholesterol gallbladder stone in 11.5% (males 11%, females 12%) of 208 diabetic patients at our clinic. All of them were over 40 years old. The prevalence of cholesterol gallbladder stones was related to the decrease in motor nerve conduction velocity in the male diabetic patients (p less than 0.05). We observed that method of treatment had no definite effect on the prevalence of gallbladder stones. Fifty-four percent of the diabetic patients was normolipidemic in both sexes. Obesity was present in 64% of the female cholesterol gallbladder stone patients. Our data suggest that age, obesity and poor contraction of the gallbladder could be high risk factors for cholesterol gallstone formation.
我们对在我们诊所接受胆结石手术的患者以及糖尿病患者进行了调查，以确定胆固醇性胆囊结石的发生与年龄、肥胖、高脂血症、糖尿病和神经病变之间是否存在显著关系。在647例接受手术的患者中，与胆红素钙结石和黑色结石相比，胆固醇结石与糖尿病或高脂血症的相关性不高。接受手术的男性患者中87%和女性患者中88%年龄超过40岁。在手术中检测出胆结石的女性患者中，36%为肥胖者。我们在我们诊所的208例糖尿病患者中发现11.5%（男性11%，女性12%）有胆固醇性胆囊结石。他们均年龄超过40岁。男性糖尿病患者中胆固醇性胆囊结石的患病率与运动神经传导速度降低有关（p<0.05）。我们观察到治疗方法对胆囊结石的患病率没有确切影响。糖尿病患者中54%的男女血脂正常。女性胆固醇性胆囊结石患者中64%存在肥胖。我们的数据表明，年龄、肥胖和胆囊收缩不良可能是胆固醇结石形成的高危因素。
