von Kummer R, Scharf J, Back T, Reich H, Machens H G, Wildemann B
Neurologische Universitätsklinik, Heidelberg, Federal Republic of Germany.
Stroke. 1988 May;19(5):594-7. doi: 10.1161/01.str.19.5.594.
The effect of isovolemic hemodilution with dextran 40 on local cerebral blood flow was measured in eight cats by means of the hydrogen clearance technique. Under normotension the decrease of hematocrit from 35% to 25% causes a sudden increase of up to 30% in local cerebral blood flow. After lowering the mean arterial blood pressure from 140 to 80 mm Hg, hemodilution did not alter cerebral blood flow significantly. From this observation it is concluded that the increase of cerebral blood flow following hemodilution is caused by compensatory vasodilatation and not by reduction of blood viscosity. This could imply that hemodilution cannot improve blood flow in areas of impaired autoregulation.
采用氢清除技术，在8只猫身上测量了用右旋糖酐40进行等容血液稀释对局部脑血流量的影响。在血压正常的情况下，血细胞比容从35%降至25%会导致局部脑血流量突然增加高达30%。在将平均动脉血压从140毫米汞柱降至80毫米汞柱后，血液稀释并未显著改变脑血流量。从这一观察结果可以得出结论，血液稀释后脑血流量的增加是由代偿性血管舒张引起的，而不是由血液粘度降低引起的。这可能意味着血液稀释不能改善自身调节受损区域的血流。
