循环单核细胞趋化蛋白-1 水平与多囊卵巢综合征的相关性：一项荟萃分析。
Association of circulating monocyte chemoattractant protein-1 levels with polycystic ovary syndrome: A meta-analysis.
机构信息
Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Am J Reprod Immunol. 2021 Aug;86(2):e13407. doi: 10.1111/aji.13407. Epub 2021 Mar 9.
PROBLEM
Polycystic ovary syndrome (PCOS) is a common hormonal disorder that has a huge impact on the human infertility. Increased levels of various circulating inflammatory cytokines have been observed in PCOS patients, which can contribute to the pathogenesis of PCOS. Monocyte chemoattractant protein-1 (MCP-1), a secretory chemokine, is a potent chemotactic factor that recruits monocytes/macrophages to inflammatory foci. Several previous studies comparing the circulating MCP-1 levels between non-PCOS and PCOS patients have yielded contradictory results. Therefore, the aim of this meta-analysis was to investigate whether circulating MCP-1 levels vary between non-PCOS and PCOS patients.
METHODS
Research articles published before November 11, 2020, were screened to identify eligible studies. Heterogeneity, sensitivity, and publication bias were analyzed using STATA software. Standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated by the STATA software using a random-effects model.
RESULTS
11 studies were included in this meta-analysis involving 897 individuals: 368 non-PCOS patient and 529 PCOS patients. Our pooled meta-analysis results show that circulating MCP-1 levels were significantly higher in PCOS patients than in non-PCOS patients (SMD = 0.84, 95% CI = [0.37, 1.31], Z = 3.50, p < 0.01). However, due to the limited number of studies included in this meta-analysis, subgroup analysis determined that circulating MCP-1 levels were not significantly varied between obese non-PCOS and obese PCOS patients (SMD = 0.42, 95% CI = [-0.65, 1.49], Z = 0.77, p = 0.442) as well as between non-PCOS and PCOS patients without obesity (SMD = 2.04, 95% CI = [-0.84, 4.93], Z = 1.39, p = 0.166). In addition, circulating MCP-1 levels were also not significantly different between obese and non-obese PCOS patients (SMD = -0.04, 95% CI = [-0.68, 0.60], Z = 0.11, p = 0.909).
CONCLUSION
Our findings reveal that circulating MCP-1 levels are upregulated in women with PCOS and are associated with an increased risk of PCOS.
问题
多囊卵巢综合征（PCOS）是一种常见的激素紊乱疾病，对人类不育有很大的影响。已经观察到 PCOS 患者体内各种循环炎症细胞因子水平升高，这可能导致 PCOS 的发病机制。单核细胞趋化蛋白-1（MCP-1）是一种分泌趋化因子，是一种有效的趋化因子，可招募单核细胞/巨噬细胞到炎症部位。几项比较非 PCOS 和 PCOS 患者循环 MCP-1 水平的先前研究得出了相互矛盾的结果。因此，本荟萃分析的目的是研究非 PCOS 和 PCOS 患者之间循环 MCP-1 水平是否存在差异。
方法
筛选截至 2020 年 11 月 11 日之前发表的研究文章，以确定合格的研究。使用 STATA 软件分析异质性、敏感性和发表偏倚。使用 STATA 软件通过随机效应模型计算标准化均数差（SMD）及其 95%置信区间（CI）。
结果
这项荟萃分析共纳入了 11 项研究，涉及 897 人：368 名非 PCOS 患者和 529 名 PCOS 患者。我们的荟萃分析结果表明，PCOS 患者的循环 MCP-1 水平明显高于非 PCOS 患者（SMD=0.84，95%CI=[0.37, 1.31]，Z=3.50，p<0.01）。然而，由于本荟萃分析纳入的研究数量有限，亚组分析确定肥胖非 PCOS 和肥胖 PCOS 患者之间循环 MCP-1 水平没有明显差异（SMD=0.42，95%CI=[-0.65, 1.49]，Z=0.77，p=0.442），非肥胖非 PCOS 和非肥胖 PCOS 患者之间循环 MCP-1 水平也没有明显差异（SMD=2.04，95%CI=[-0.84, 4.93]，Z=1.39，p=0.166）。此外，肥胖和非肥胖 PCOS 患者之间循环 MCP-1 水平也没有明显差异（SMD=-0.04，95%CI=[-0.68, 0.60]，Z=0.11，p=0.909）。
结论
我们的研究结果表明，PCOS 患者的循环 MCP-1 水平升高，并与 PCOS 的发生风险增加相关。
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