Department of Neurology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.
Department of Life Sciences, The Centre for Inflammation Research and Translational Medicine (CIRTM), Brunel University London, Uxbridge, Middlesex, UK.
Microcirculation. 2021 Apr;28(3):e12689. doi: 10.1111/micc.12689. Epub 2021 Mar 21.
The intertwined processes of thrombosis and inflammation (termed "thrombo-inflammation") are significant drivers of cerebrovascular diseases, and as such, they represent prime targets for drug discovery programs focusing on treatment and management of cerebrovascular diseases. Most cerebrovascular events result from chronic systemic microcirculatory dysfunction due to underlying conditions, for example, hypertension, diabetes mellitus, coronary artery disease, dyslipidemia, and sickle cell disease. Immune cells especially neutrophils play a critical role in the onset and maintenance of neuroinflammatory responses in the microcirculation. Neutrophils have the ability to drive both inflammatory and anti-inflammatory/pro-resolution effects depending on the underlying vascular state (physiological vs. pathological). In this article, we highlight the pathophysiological role of neutrophils in stroke and discuss ongoing pharmacotherapeutic strategies that are focused on identifying potential therapeutic targets for enhancing neuroprotection, mitigating inflammatory pathways, and enabling resolution.
血栓形成和炎症的交织过程（称为“血栓炎症”）是脑血管疾病的重要驱动因素，因此，它们是专注于治疗和管理脑血管疾病的药物发现计划的主要目标。大多数脑血管事件是由于潜在疾病（例如高血压、糖尿病、冠状动脉疾病、血脂异常和镰状细胞病）导致的慢性系统性微循环功能障碍引起的。免疫细胞，特别是中性粒细胞，在微循环中的神经炎症反应的发生和维持中起着关键作用。中性粒细胞具有根据潜在血管状态（生理与病理）驱动炎症和抗炎/促解决作用的能力。在本文中，我们强调了中性粒细胞在中风中的病理生理学作用，并讨论了正在进行的药物治疗策略，这些策略专注于确定潜在的治疗靶点，以增强神经保护、减轻炎症途径和促进解决。
