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冠状动脉疾病和炎症激活干扰外周组织电阻抗光谱特征-初步报告。

Coronary Artery Disease and Inflammatory Activation Interfere with Peripheral Tissue Electrical Impedance Spectroscopy Characteristics-Initial Report.

机构信息

Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.

Department of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.

出版信息

Int J Environ Res Public Health. 2023 Feb 3;20(3):2745. doi: 10.3390/ijerph20032745.

DOI:10.3390/ijerph20032745
PMID:36768108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9915397/
Abstract

BACKGROUND

The electrical properties of cells and tissues in relation to energy exposure have been investigated, presenting their resistance and capacitance characteristics. The dielectric response to radiofrequency fields exhibits polarization heterogeneity under pathological conditions. The aim of the study was to analyze the differences in changes in resistance and capacitance measurements in the range from 1 kHz to 1 MHz, combined with an assessment of the correlation between the results of electrical impedance spectroscopy (EIS) and inflammatory activation.

METHODS

In the prospective study, EIS was performed on the non-dominant arm in 29 male patients (median (Q1-Q3) age of 69 (65-72)) with complex coronary artery disease and 10 male patients (median (Q1-Q3) age of 66 (62-69)) of the control group. Blood samples were collected for inflammatory index analysis.

RESULTS

The logistic regression analysis revealed a negative correlation with inflammatory indexes, including neutrophil to lymphocyte ratio (NLR) in the CAD group in the frequency of 30 kHz ( = 0.038, r = -0.317) regarding EIS resistance measurements and a positive correlation in CAD group in the frequency of 10 kHz ( = 0.029, r = -0.354) regarding EIS capacitance.

CONCLUSIONS

The bioelectric characteristics of peripheral tissues measured by resistance and capacitance in EIS differ in patients with coronary artery disease and in the control group. Electrical impedance spectroscopy reveals a statistically significant correlation with inflammatory markers in patients with CAD.

摘要

背景

已经研究了与能量暴露有关的细胞和组织的电学特性，呈现出它们的电阻和电容特性。在病理条件下，射频场的介电响应表现出极化异质性。本研究的目的是分析电阻和电容测量在 1 kHz 至 1 MHz 范围内变化的差异，同时评估电阻抗谱（EIS）结果与炎症激活之间的相关性。

方法

在这项前瞻性研究中，对 29 名患有复杂冠状动脉疾病的男性患者（中位数（Q1-Q3）年龄 69（65-72））和 10 名对照组男性患者（中位数（Q1-Q3）年龄 66（62-69））的非优势手臂进行了 EIS。采集血液样本进行炎症指数分析。

结果

逻辑回归分析显示，CAD 组中电阻 EIS 测量在 30 kHz 时与炎症指标（包括中性粒细胞与淋巴细胞比值 NLR）呈负相关（ = 0.038，r = -0.317），而在 CAD 组中在 10 kHz 时与 EIS 电容呈正相关（ = 0.029，r = -0.354）。

结论

EIS 测量的外周组织电阻和电容的生物电特性在冠状动脉疾病患者和对照组中存在差异。电阻抗谱与 CAD 患者的炎症标志物具有统计学显著相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/197b6d437c4f/ijerph-20-02745-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/21fc09bfc866/ijerph-20-02745-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/b933c7b1ab2e/ijerph-20-02745-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/733ddf2bedbb/ijerph-20-02745-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/8ceb8dfb71ec/ijerph-20-02745-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/197b6d437c4f/ijerph-20-02745-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/21fc09bfc866/ijerph-20-02745-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/b933c7b1ab2e/ijerph-20-02745-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/733ddf2bedbb/ijerph-20-02745-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/8ceb8dfb71ec/ijerph-20-02745-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ea/9915397/197b6d437c4f/ijerph-20-02745-g005.jpg

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