甲基黄嘌呤类药物对致热原诱导的体温过高的影响。
Effects of methylxanthine drugs on pyrogen-induced hyperthermia.
作者信息
Dascombe M J
出版信息
Eur J Pharmacol. 1977 Oct 15;45(4):389-92. doi: 10.1016/0014-2999(77)90280-1.
PMID:336383
Abstract
The hyperthermic response to pyrogen was not potentiated by caffeine or theophylline administered i.p. into cats or rabbit. Injection of these drugs into the anterior hypothalamus or into the third cerebral ventricle in cats was also without effect on pyrexia. These results support the hypothesis that cyclic AMP in the anterior hypothalamus does not mediate pyrogen-induced hyperthermia in cats.
摘要
腹腔注射咖啡因或茶碱并不会增强猫或兔子对热原的热反应。向猫的下丘脑前部或第三脑室注射这些药物也不会对发热产生影响。这些结果支持了以下假说：猫下丘脑前部的环磷酸腺苷不会介导热原诱导的体温过高。
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